摘要
目的检测与分析肺癌骨转移瘤患者尿I型胶原交联氨基末端肽(uNTX)水平,评价其与骨转移病情发展和疗效的关系。方法研究对象为正常组33例;肺癌组31例;肺癌骨转移组30例。分别测定3组uNTX水平,同时进行尿脱氧吡啶酚及血清AKP活性和Ca2+浓度的测定,肺癌骨转移组进行了治疗前后uNTX水平对比。结果肺癌骨转移组uNTX水平明显高于其他两组,其治疗前后uNTX水平也有显著性差异。结论肺癌骨转移时uNTX水平会发生异常,uNTX水平与骨转移的发生呈正相关,uNTX敏感度高于尿脱氧吡啶酚及血清AKP活性和Ca2+浓度,在预测肺癌骨转移瘤和监测病变进程中有重要临床价值。
Objective To study the value of urinary type I collagen cross-linked N-telopeptides （uNTX） measurement in lung cancer patients with bone metastases. Methods 33 healthy controls, 31 lung cancer patients without bone metastases, and 30 lung cancer patients with bone metastases included in the study, uNTX was measured with test kit of uNTX, The serum alkaline phosphatascs （AKP） and calcium concentration were also measured. Results The level of uNTX in lung cancer patients with bone metastases was significantly higher than in that in the healthy controls and in lung cancer patients without bone metastases. Conclusion uNTX is positively correlated with bone metastasis in lung cancer. It is more sensitive than serum AKP and plasma calcium concentration, as well as Pyridines/ urine Phenols. UNTX is significant in differentiating and monitoring bone metastasis in lung cancer patients, uNTX is useful in predicting bone metastases and monitoring disease progress in lung cancer
出处
《实用癌症杂志》
2007年第2期167-170,共4页
The Practical Journal of Cancer
关键词
肺恶性肿瘤
I型胶原交联氨基末端肽
骨转移瘤
Lung neoplasm
Urinary type I collagen cross-linked N-telopeptides（uNTX）
Bone metastasis
