摘要
目的：探讨白细胞介素－8（IL－8）、肿瘤坏死因子（TNF－α）在哮喘中的意义。方法：用双抗体夹心ELISA法测定30例重症哮喘病人血清IL－8和TNF－α水平。结果：重症哮喘病人血清IL－8和TNF－α水平显著高于健康人和哮喘缓解期病人（P＜0．01），而缓解期与健康对照两组间比较无显著差异（P＞0．05）。血清IL－8、TNF－α与末稍血中嗜酸性粒细胞（EC）水平呈正相关（P＜0．01）。重症哮喘病人EC水平升高，缓解期亦明显高于健康对照组（P＜0．05）。结论：血清IL－8和TNF－α参与哮喘发作的过程，并且与气道炎症反应及变态反应有关，阻断它们的过度效应，对防治哮喘发作有益。
Aim: To Study the changes of serum interleukin-8 (IL-8) and tumor necmsis factor alpha (TNF-α) in severe asth maic patients. Methods: The levels of serum IL-8 and TNF-α in a group of 30 cases of severe asthma were detected by using two-step sandwich ELISA technique. Results: In comparison with the control and asthma remmission, serum IL-8 and TNF-α levels of severe asthma were significanily higher than both of them (P < 0.01 ), while there were no significant differences be tween the asthma remmission and control (P > 0.05 ). The postitive correlations were found between serum IL-8 level and eosno phil granulocyte count (EC), and between serum TNF-α level and EC (P < 0.01 ). The EC in patients with severe asthma was significantly higher than that in control (P < 0.01 ). The EC in patients with asthma remmission was the significantly higher than that in control (P < 0.05). Conclusion: IL-8 and TNF-α play a role in the pathophysiology, and these are coneerned with respiratory tract inflammatory and allergic response.
出处
《急诊医学》
CSCD
1998年第3期156-158,共3页
关键词
重症哮喘
白细胞介素-8
肿瘤坏死因子
嗜酸性粒细胞
Severe asthma Interleukin-8 Tumor necrosis factor alpha Eosinophil granulocyte count
