摘要
目的:研究老年社区获得性肺炎患者前白蛋白(PA)及C-反应蛋白(CRP)的变化,探讨其与病情严重程度及预后的关系。方法:测定我院内科80例老年社区获得性肺炎患者入院第1天与第7天的CRP、PA、SIRS评分和APACHEⅡ评分,按预后把患者分成死亡组和存活组。结果:死亡组入院第1天CRP、PA与存活组比较无差异,SIRS评分和APACHEⅡ评分均大于存活组(P<0.05);死亡组第7天PA较前降低(P<0.05),CRP、SIRS评分和APACHE Ⅱ较前相比无差异(P>0.05);存活组第7天CRP、SIRS评分和APACHEⅡ评分较第1天降低,PA较前升高(P<0.05),与死亡组相比有显著性差异。结论:CRP和PA与老年社区获得性肺炎患者病情严重程度具有相关性。CRP持续高水平与PA持续低水平是预后不良的表现,动态观察CRP和PA对预测老年社区获得性肺炎患者预后有重要临床价值。
Objective：To study the Changes of C-reactive protein （CRP）and prealbumin （PA） levels in old patients with community acquired pneumonia so as to explore the relation to the severity of disease and prognosis Methods：CRP and PA levels of 80 old patients with community acquired pneumonia were measured on 1st and 7th day.SIRS Score and APACHE Ⅱscore were documented.According to prognosis,patients were divided into death group and survival group.Results：The levels of CRP and PA on 1^st day were of no significant difference between death group and survival group,but SIRS score and APACHE Ⅱ score in death group were higher than that in survival group on 1^st and 7^th day;The levels of CRP, SIRS score and APACHE Ⅱ score in death group were no significant difference on between 1^st and 7^th.but the level of PA on 7^th was much lower than that on 1^st ,The levelS of CRP, SIRS score and APACHE Ⅱ score in survival group on 7^th day were lower than that on 1^st day. The level of PA was increased.Conclusions：The levels of CRP and PA were associated with severity of old patients with community acquired pneumonia.Persistent high level of CRP and low level of PA indicated unfavourable prognosis.It is important to evaluate the severity of disease and predict prognosis in old patients with community acquired pneumonia by combined dynamic observation of CRP and PA level.
出处
《中国医药导刊》
2009年第7期1098-1099,共2页
Chinese Journal of Medicinal Guide
