摘要
目的观察度洛西汀与氟西汀对首发抑郁症的临床疗效和安全性。方法对65例首次发病的抑郁症患者随机分为度洛西汀组(33例)与氟西汀组(32例),分别用度洛西汀60mg/日与氟西汀20mg/d治疗6周。以汉密尔顿抑郁量表(HAMD-17)评定临床疗效,以不良反应量表(TESS)和实验室监测评价安全性。于基线时、第1、2、4、6周末分别评定各量表。结果共收集完成6周治疗的病例62例,其中度洛西汀组32例、氟西汀组30例。度洛西汀痊愈率50%、有效率84.4%,氟西汀组痊愈率50%、有效率80%。两组比较差异无统计学意义(P>0.05)。自第2周末开始,两组间焦虑/躯体化因子分比较差异有统计学意义(P<0.05～0.01),度洛西汀组焦虑/躯体化因子分下降较氟西汀组明显。度洛西汀的不良反应与氟西汀相似,主要为食欲减退、恶心、口干、头痛头昏、疲乏。结论度洛西汀治疗首发抑郁症安全、有效,与氟西汀相似,尤其改善抑郁症患者的焦虑、躯体症状效果明显,优于氟西汀。
Objective To compare the clinical efficacy and safety of duloxetine and fluoxetine in the treatment of first episode depression. Methods Sixty-five eases with first episod of depression were randomly divided into the duloxetine group and the fluoxetine group, 33 cases received duloxetine 60mg/day while 32 eases received fluoxetine 20mg/day were treated for 6 weeks. The elinical efficacy was assessed by scores of Hamilton Rating Scale for Depression（ HAMD-17 ）, adverse reactions were evaluated by Treatment Emergent Symptom Scale（TESS ）. Results Tirty-two eases in duloxetine group and 30 cases in fluoxetine group completed the treatment for 6 weeks. Effects of both groups were similar after 6 weeks. But there was statistically significant difference between the two groups anxiety/somatization factor score of HAMD at the second（ P 〈 0.05 - 0.01 ）. Side effects of both were similar, mainly lack of appetite, nausea, dry mouth,headache,dizziness, and fatigue. Conclusion Duloxetine is as effective and safe as fluoxetine in the treatment of first episode depression, but to depressive patients with anxiety, somatic symptoms have better efficacy compared with fluoxetine.
出处
《中国现代医生》
2009年第21期85-86,共2页
China Modern Doctor
关键词
度洛西汀
氟西汀
首发抑郁症
疗效
安全性
对照研究
Duloxetine
Fluoxetine
First episode depression
Efficacy
Safety
Controlled study
