摘要
目的目前对儿童抽动-秽语综合征（TS）的治疗主要以口服药物为主，但鉴于药物的不良反应及每日1-2次口服药物不方便，导致患儿依从性差。该文探讨可乐定透皮贴剂治疗TS的临床疗效和安全性。方法将119例5-17岁TS患儿分为两组，治疗组65例采用可乐定透皮贴剂；对照组54例给予氟哌啶醇口服。4周后观察两组的疗效。疗效评定采用耶鲁大体抽动严重程度量表（YGTSS）测定。结果贴剂治疗组YGTSS减分率（61.5±7.5）%，对照组减分率（41.0±6.3）%，两组减分率通过χ^2检验差异有显著性（P〈0.05）。贴剂治疗组53例有效，有效率为81.5%，对照组36例有效，有效率为67.5%，差异无显著性。贴剂治疗组1例出现血压下降、头晕反应，停药后恢复。对照组2例出现轻度的颈肌张力增高，4例出现轻度嗜睡，疲乏。结论可乐定透皮贴剂对治疗儿童TS有明显疗效，且不良反应少而轻微，方便，易于接受。
Objective Children with Tourette＇s syndrome （TS） have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children. Methods A total of 119 children with TS were randomly treated with the clonidine transdermal patch （n = 65） or with oral haloperidol （n = 54）. The therapeutic efficacy was assessed based on the results of the Yale Global Tic Severity Scale （ YGTSS ） 4 weeks after treatment. Results The clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores （ 61.5 ± 7.5% ） than that in the haloperidol group （41.0± 6.3% ; P 〈0.05）. Clonidine transdermal patch treatment was effective in 53 patients （81.5%） and 36 patients （67.5%） showed effective to oral haloperidol （ P 〉 0.05 ）. Mild side effects （ decrease of blood pressure and dizziness ） were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group. Conclusions Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2009年第7期537-539,共3页
Chinese Journal of Contemporary Pediatrics
