摘要
本文观察了骨髓造血基质细胞贴壁层及细胞悬液对 GM-CFU-C 生长的影响及照射后的变化。实验结果表明,骨髓基质细胞贴壁层及细胞悬液均有增高 GM-CFU-C 产率的作用。这种刺激性影响与基质细胞贴壁层的细胞密度和细胞悬液的浓度没有依赖关系。1～5Gyγ线照射的骨髓基质细胞贴壁层和细胞悬液支持 GM-CFU-C 集落生成的作用明显削弱。文中讨论了造血基质细胞的辐射损伤在放射病骨髓综合征发病机理中的意义。
The effects of adherent marrow stromal cell layer and stromal cells harvested in long- term liquid culture system on the growth of GM-CFU-C were investigated and compared. Results showed that marrow stromal cells could stimulate the colony formation of GM-GFU- C in semisolid culture system in vitro.The yields of GM-CFU-C increased from 25 to 50%. These stimulating effects of marrow stromal cells were significantly weakened after 1-5 Gy of γ-irradiation. The mechanism of the effects of marrow stromal cells on the growth of GM-CFU-C and the significance of their damage in pathogenesis of hemopoietic failure after irradiation were discussed.
出处
《军事医学科学院院刊》
CSCD
北大核心
1990年第2期81-84,共4页
Bulletin of the Academy of Military Medical Sciences
