摘要
目的研究正电子药物18F-FDG的制备与质量控制以及影响18F-FDG合成效率的因素。方法使用医用回旋加速器,通过18O(p,n)18F核反应,采用Explora FDG4全自动合成系统制备了18F-FDG静脉注射液,对于制备的药物进行质量控制与影响因素分析。结果Explora FDG4合成效率65%,18F-FDG放化纯度99% 18F-FDG其他指标符合药典质量要求,反应体系中残留的水等影响合成效率。结论制备的18F-FDG静脉注射液使用临床PET-CT检查。
Objective To develop the preparation quality control and influential factor of ^18F-FDG syn- thesis , a positron emission tomography imaging agent. Methods ^18F-FDG was synthesis automatically via nuclear ^18O（p ,n） 18 F by medical cyclotron and Explora FDG4 automatic synthesis system. To develop influential factor of ^18F-FDG preparation. Results The corrected yield was about 65% and radiochemical purity was over 99%. The rudimental water in reaction system affect the yield of ^18F-FDG. Conclution ^18F-FDG for intravenous injection was suitable for PET-CT scan.
出处
《中国实用医药》
2009年第5期30-31,共2页
China Practical Medicine
