摘要
鸡干扰素主要由活化的T细胞、NK细胞产生,具有广谱抗病毒、抗肿瘤和免疫调节等作用。鸡干扰素-γ基因已经被成功克隆并在Vero细胞和大肠杆菌等表达系统中表达,并且被证明与鸡球虫病的免疫有关,它可激活巨噬细胞,增强K细胞、NK细胞的抗感染作用。另外,ChIFN-γ可用作免疫增强剂,具有广泛的应用前景。
Chicken interferon comes from the activated T cells, NK cells. It has many functions, such as broad-spectrum anti-viral, anti-tumor and the role of immunity regulation. Chicken interferon-γ gene has been cloned successfully in vero cells and E. coli and so on. Also chicken interferon-γ gene has been expressed and proved to enhance the immunity function against chicken coccidiosis. It could activate macrophages and reinforce the role of anti-infective of K cells, NK cells. In addition, ChlFN-γcan be used as immunoenhancer, which has a wide range of application.
出处
《中国畜牧兽医》
CAS
北大核心
2009年第7期178-181,共4页
China Animal Husbandry & Veterinary Medicine
基金
山西省科技攻关项目(052011)
山西高校科技研究开发项目(20051222)
山西农业大学科技创新基金项目(200002)
关键词
鸡
干扰素-Γ
基因表达
球虫病
chicken
interferon-γ
gene expression
coccidiosis
