摘要
目的调查新疆库尔勒市塔什店镇哈满沟煤矿内脏利什曼病的流行现况。方法2008年6月采用回顾性调查与现况调查相结合,对哈满沟矿区所有居民进行逐户入室调查。内容包括既往有无疑似内脏利什曼病病史,部分居民进行利什曼素皮内试验,并对15岁以下儿童皮内试验阴性者进行体检(肝、脾触诊)和rk39免疫层析试条检测,具备内脏利什曼病症状和体征、试条阳性者进行骨髓穿刺,镜检是否感染利什曼原虫无鞭毛体。在居民点及附近野外捕集白蛉,解剖鉴定白蛉,并检查前鞭毛体有无自然感染。结果接受利什曼素皮内试验185人,阳性39例,阳性率为21.1%(39/185)。在当地居住不足6年的成年人和在当地出生的5岁以下儿童共45人,均为阴性;在当地居住6年以上者阳性率为27.9%(39/140)。15岁以下儿童皮内试验阴性者(81人)接受rk39免疫层析试条检测,阳性1例,经骨髓穿刺镜检见利什曼原虫无鞭毛体,确诊为内脏利什曼病。捕获的12只白蛉,经剖检鉴定为亚历山大白蛉(Phlebotomus alexandri),其中1只雌蛉利什曼原虫前鞭毛体阳性。结论哈满沟矿区为内脏利什曼病流行区。
Objective To investigate the epidemiological status of visceral leishmaniasis in Hamangou coal mine area of Korla City of Xinjiang Uygur Autonomous Region. Methods Based on a hint of possible existence of patients, a retrospective survey was carried out house by house to find cases with suspected signs/symptoms of the disease. Meanwhile, a survey on current status was conducted, including physical examination （liver and spleen palpation） to those less than 15 years-old, leishmanin skin test and rk39 immunochromatographic strip test for part of the residents. Bone marrow smears were examined for the cases with clinical signs/symptoms and positive rk39 strip test. Sandflies were collected using routine methods in and around the area, identified, and dissected to find infection of promastigotes. Results Leishmanin skin test was performed in 185 people with a positive rate of 21.1% （39/185）, 39 out of 140 local residents who have lived there for more than 6 years showed positive （27.9%）, while all residents who have lived less than 6 years and children under 5 years old were negative. Of the 81 children under 15 years old with a negative skin test, one showed positive for rk39 strip test, and leishmania body was found in the bone marrow smear of this case, so confirmed as visceral leishmaniasis. 12 sandfies were identified as Phlebotomus alexandri, and natural infection with promastigotes was found in one sandly. Conclusion The investigation confirms that visceral leishmaniasis is endemic in the Hamangou coal mine area.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2009年第3期237-240,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
科技部自然资源平台项目(No.2005DKA21104)~~
