摘要
目的:利用气相色谱/质谱联用技术检验一例硬膜外麻醉死亡人体内的布比卡因含量。方法:样品碱化后乙醚萃取,气相色谱/质谱联用法检测布比卡因。结果:布比卡因在硬膜外麻醉死后人血、心、肝、肾、脑、脑脊液、颈段脊髓、胸段脊髓(T5-9)(T10-12)、腰段脊髓和骶段脊髓中含量分别为2.369μg/ml、1.221μg/g、1.138μg/g、1.149μg/g、0.393μg/g、63.311μg/ml、0.491μg/g、54.230μg/g、96.366μg/g、156.690μg/g和248.040μg/g。结论:布比卡因在硬膜外麻醉死亡人脊髓和脑脊液中含量较高,排除其它死因条件下,推断其为硬膜外麻醉误入蛛网膜下腔死亡。
Objective：To determine the bupivacaine after epidural anesthesia in a person by GC/MS. Methods：The samples were alkalified and extracted by ether. The bupivacaine was analyzed by GC/MS. Results： The concentration of bupivacaine in blood, heart, liver, kidney, brain, CSF and different spinal cord were 2. 369 ug/ml, 1. 221 ug/g, 1. 138 ug/g, 1. 149 ug/g, 0.393 ug/g, 63.311 ug/ml, 0.491 ug/g, 54.230 ug/g, 96.366 ug/g, 156.690 ug/g and 248.040 ug/g, respectively. Conclusion：The concentration of bnpivacaine in CSF and spinal cord were higher than in other samples. And the deoolh was caused by anesthesia accident.
出处
《中国卫生检验杂志》
CAS
2009年第7期1453-1454,共2页
Chinese Journal of Health Laboratory Technology
基金
"十一五"国家科技支撑计划项目(2007BAK26B05)
山西省高等学校中青年拔尖创新人才支持计划项目(2008)
