摘要
以冰醋酸为溶剂,香兰素为原料,AlBr3为催化剂,HBrO3与KBrO3为溴化剂合成了5-溴香兰素。采用正交实验法考察了影响收率的因素。最佳条件为:香兰素、KBrO3与AlBr3的物质的量的摩尔比为1:0.5:0.056,反应时间6.0h,反应温度30℃。在优化条件下收率可达90.4%。产物结构通过IR、1HNMR、熔点测定和元素分析得以确认。
5-bromo-vanillin was synthesizedby using vanillin as raw material, aluminium chloride as catalyst, hydrobromie acid and potassium bromate as brominating agent and acetic acid as solvent.Factors influencing the yield were investigated by the orthogonal experimental method.The optimum conditions are as follows：Vanillin： potassium bromate ：aluminium chloride is 1mol：0.5mol：0.056mol, reaction time is 6.0h ,reaction temperature is 30℃. The yield is above 90.4% under the optimum conditions. The title compound was characterized by IR,1H NMR,mp. Measurement and element analysis.
出处
《化学工程师》
CAS
2009年第7期67-68,共2页
Chemical Engineer
