连续输注异丙酚和咪达唑仑对老年患者免疫功能的影响被引量：10

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摘要目的:比较咪达唑仑和异丙酚对老年患者免疫功能的影响。方法:40例年龄65～73岁、需要大于2d连续镇静治疗的外科ICU患者随机分成2组,每组20例,持续给予异丙酚、咪达唑仑静注,比较48h后血浆细胞因子的含量。结果:异丙酚组与输注前比较IL-1β、IL-6、TNF-α有显著性增加,咪达唑仑组所有的细胞因子均显著性减少;2组IL-8比输注药物前明显减少,咪达唑仑组更为显著;异丙酚组与输注前比较IL-2非常显著性降低(P<0.01),而咪达唑仑组没有明显的变化;异丙酚组INFγ-比输注前有显著性增加(P<0.05),而咪达唑仑组没有明显的变化。结论:咪达唑仑和异丙酚均能促进持续镇静的老年患者产生致炎性和抗炎性细胞因子,且咪达唑仑较异丙酚有明显的抑制炎症作用,对老年患者更为有利。

作者林洪启

机构地区河南省人民医院麻醉科

出处《中国医院药学杂志》 CAS CSCD 北大核心 2009年第14期1239-1240,共2页 Chinese Journal of Hospital Pharmacy

关键词咪达唑仑异丙酚细胞因子

分类号 R979.5 [医药卫生—药品]

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1张银中,叶铁虎,任洪智,黄宇光,卜玉芬.异丙酚对白介素-6所致中性粒细胞凋亡障碍的影响[J].中华麻醉学杂志,2002,22(6):329-331. 被引量：24
2罗艳,于布为.异丙酚对系统性炎性反应综合征大鼠免疫因子的影响[J].中华麻醉学杂志,2002,22(10):615-618. 被引量：17
3任宪凤,林长赋,孟繁有,李文志,丁文刚,李璐璐.异丙酚或异氟烷复合麻醉对肺癌根治术病人细胞免疫功能的影响[J].中华麻醉学杂志,2006,26(9):773-776. 被引量：5
4范隆,王国林.咪达唑仑和丙泊酚对炎性反应的影响[J].国外医学（麻醉学与复苏分册）,2005,26(1):48-51. 被引量：9

二级参考文献53

1Galley HF, Dubbels AM, Webster NR, et al. The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes. Anesth Analg, 1998,86(6): 1289-1293.
2O'Donnell NG, Mcsharry CP, Wilkinson PC, et al. Comparison of the inhibitory effect of propofol, thiopentone and midazolam on neutrophil polarization in vitro in the presence or absence of human serum albumin. Br J of Anaesth, 1992,69(1 ) :70-74.
3Hulse D, Kusel JR, O'Donell NG, et al. Effect of anesthetics on the mem brane mobility and locomotor responses of human neutrophils. FEMS lmmunol Med Microbiol, 1994,8(3):241-248.
4Mikawa K, Akamatsu H, Nishina K, et al. Propofol inhibits human neutrophil functions. Anesth Analg, 1998,87(3):695-700.
5Inada T, Taniuchi S, Shingu K, et al. Propofol depressed neutrophilhydrogen peroxide production more than midazolam, whereas adhesionmolecule expression was minimally affected by both anesthetics in rats with abdominal sepsis. Anesth Analg,2001,92(2) :437-441.
6Szekely A, Heindl B, Zahler S, et al. Nonuniform behavior of intravenous anesthetics on postisehemic adhesion of neutrophils in the guinea pig heart. Anesth Analg,2000,90(6): 1293-1300.
7Weiss M, Bnhl R, Medve M, et al. Tumor necrosis factor-c modulates the selective interference of hypnotics and sedatives to suppress N-formyl-methionyl-leucyl-pbenylalanine-induced oxidative burst formation in neutrophils. Crit Care Med, 1997,25( 1 ): 128-134.
8Heine J, Leuwer M, Scheinichen D, et al. Flow cytometry evaluation of the in vitro influence of four i. v. anaesthetics on respiratory burst of neutro phils. Br J Anaesth, 1996,77(3) :387-392.
9Heine J, Jaeger K, Osthans A, et al. Anaesthesia with propofol decreases FMLP-indueed neutrophil respiratory burst but not phagocytosis compared with isoflurane. Br J Anaesth, 2000,85(3):424-430.
10Lwis LS,Whatley RE, Cain P. Hydrogen peroxide stimulates the synthesis of plate activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. J lin Invest, 1998,82(8): 2045-2055.