摘要
目的比较两种静脉全麻药异丙酚和依托咪酯(商品名宜妥利)对重型创伤患者免疫功能的影响。方法急诊重型创伤患者20例按全麻用药不同均分为异丙酚组(P组)和依托咪酯组(E组),分别于全麻诱导前、诱导后5 min、术毕、术后1 d和术后3 d检测白介素(IL)-1、IL-2、IL-6、IL-8、肿瘤坏死因子(TNF)-α及C反应蛋白(CRP)水平。结果两组患者的IL-1和IL-8在诱导后及手术维持过程中无明显变化,而IL-2和IL-6在术毕达到最高值,TNF-α和CRP在术后1d达到最高值,相同时间点两组间免疫因子的差异无显著性。结论异丙酚和依托咪酯在诱导剂量范围内对重型创伤患者免疫功能的影响无明显差异。
Objective To compare the effects of propofol and etomidate on the immune function of patients with severe trauma. Methods Twenty severe traumatic patients undertaken emergency surgery were divided into two groups according to different general anesthetics received： Group P received propofol and Group E obtained etomidate. The plasma levels of interleukin （IL）-I, 2, 6, 8, tumor necrosis factor （TNF）-α and C-reacting protein （CRP） were detected and compared between the two groups at the time point of： before induction （TO）, 5 min after induction （T1）, end of surgery （T2）, 1 d after surgery （T3） and 3 d after surgery （T4）. Results The levels of IL-1 and IL-8 kept unchanged at all time points in both groups. IL-2 and IL-6 reached peak levels at the end of surgery, and TNF-α and CRP reached peak levels 1 d after surgery. At the same time point, the level of all immune markers were of no significant difference between the two groups. Conelmion At this induction dosage, the effects of propofol and etomidate on the immune function of severe traumat ic pat ients are of no significant difference.
出处
《上海医学》
CAS
CSCD
北大核心
2006年第3期159-161,共3页
Shanghai Medical Journal
关键词
免疫因子
应激
麻醉
全身
依托咪酯
异丙酚
Immune function
Stress
Anesthesia, general
Etomodate
Propofol
