动脉粥样硬化中他汀类药物非调脂作用研究进展
摘要
他汀类药物除调脂外,还可通过改善内皮功能,抑制炎症,抑制血栓形成,调节平滑肌和泡沫细胞来对抗动脉粥样硬化。
出处
《国外医学(老年医学分册)》
2009年第4期160-163,共4页
Foreign Medical Sciences(Geriatrics)
参考文献20
-
1Liao JK. Statins: potent vascular anti - inflammatory agent. Int J Clin Praet Suppl, 2004; 143:41 -48.
-
2John S, Schneider MP, Delles C et al. Lipid -independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. Am Heart J, 2005 ; 149 : 473.
-
3Schulze F, Lenzen H, Hanefeld C et al. Asymmetric dimethylarginine is an independent risk factor for coronary heart disease : results from the multicenter coronary artery risk determination investigating the influence of ADMA concentration ( CARDIAC ) study. Am Heart J, 2006 ; 152 ( 3 ) : 493. e1 -493. e8.
-
4Nagaoka T, Hein TW, Yoshida A et al. Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate - Rho kinase pathways. Invest Ophthaltool Vis Sci, 2007 ; 48 (2) : 825 - 832.
-
5Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX- 1 ) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells, evidence from use of alltis - ense LOX - 1 mRNA and chemical inhibitors. Arterioscler Thromb Vase Biol, 2000; 20:1116 - 1122.
-
6季亢挺,张怀勤.内皮祖细胞与他汀类药物调脂外心血管保护作用[J].心血管病学进展,2004,25(5):360-362. 被引量:8
-
7Dimmeler S, Aicher A, Vasa Met al. HMG - CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3 -kinase/Akt pathway. J Clin Invest, 2001; 108 (3): 391-397.
-
8张京梅,陶英,李志忠,李十红,白树功,陈辉,卢辛.早期应用大剂量阿托伐他汀对老年急性冠状动脉综合征患者抗炎作用的临床研究[J].中国综合临床,2007,23(3):203-205. 被引量:28
-
9Ma QL, Mo L, Yang TL et al. Effect of different doses of atorvastatin on adhesion molecules of the patients undergoing percutaneous coronary intervention. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2006; 31:914 - 916.
-
10Tousoulis D, Antoniades C, Katsi Vet al. The impact of early administration of low - dose atorvastatin treatment on inflammatory process in patients with unstable angina and low cholesterol level. Int J Cardiol, 2006; 109:48 -52.
二级参考文献35
-
1洪梅,魏文宁,胡豫,杨锐,杨焰.Plasma Levels of the Anti-inflammatory Cytokine IL-10 and Inflammatory Cytokine IL-6 in Patients with Unstable Angina[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2005,25(6):639-641. 被引量:5
-
2Sata M,Nishimatsu H,Suzuki E,et al.Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia[J].FASEB J,2001,15:2530-2532.
-
3Indolfi C,Cioppa A,Stabile E,et al.Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury[J].J Am Coll Cardiol,2000,35:214-221.
-
4Walter DH,Rittig K,Bahlmann FH,et al.Statin therapy accelerates reendothelialization:a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells[J].Circulation,2002,105:3017-3024.
-
5Assmus B,Urbrich C,Aicher A,et al.HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes[J].Circ Res,2003,92:1049-1055.
-
6Griese DP,Ehsan A,Melo LG,et al.Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts:implications for cell-based vascular therapy[J].Circulation,2003,108(21):2710-2715.
-
7Dimmeler S,Aicher A,Vasa M,et al.HMG-CoA-reductase inhibitors (statins) increase endothelial progenitor cells via the PI3 kinase/Akt pathway[J].J Clin Invest,2001,108:391-397.
-
8Corsini A,Pazzucconi F,Pfister P,et al.Inhibitor of proliferation of arterialsmooth-muscle cells by fluvastatin[J].Lancet,1996,348:1584.
-
9Arasaha T,Masuda H,Takahashi T,et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science,1997,275:964-967.
-
10Llevadot J,Murasawa S,Kureishi Y,et al.HMG-CoA reductase inhibitor mobilizes bone-marrow derived endothelial progenitor cells[J].J Clin Invest,2001,108:399-405.
共引文献40
-
1张寒冰.浅析瑞舒伐他汀对老年高血压动脉弹性及炎性因子的影响[J].求医问药(下半月),2013(5):294-296.
-
2诸培佳,李月华.他汀类药物对心血管系统的保护效应[J].中国临床康复,2006,10(28):129-131. 被引量:1
-
3罗卡兰,李伟,黄达枚.心肌梗塞后倍他乐克与他汀类药物对心脏的保护[J].贵阳医学院学报,2006,31(5):430-432. 被引量:4
-
4董彬,王庸晋,刘玲.阿托伐他汀对ACS患者血管内皮功能及炎症因子的影响[J].长治医学院学报,2008,22(2):145-148. 被引量:2
-
5石先辉,贾如意.阿托伐他汀在急性冠状动脉综合征中的抗炎作用及临床应用[J].医学综述,2008,14(12):1888-1890. 被引量:25
-
6李昭华,钟远伦.阿托伐他汀治疗颈动脉粥样硬化疗效观察[J].西部医学,2009,21(7):1180-1181. 被引量:5
-
7熊攀,周莉,常以芳,董爱芝.曲美他嗪联合阿托伐他汀治疗原发性高血压伴阵发性心房颤动的疗效观察[J].中国综合临床,2009,25(7):735-738. 被引量:8
-
8杨克平,李欣,胡钢,许臣洪,李承彬,李琳芸.洛伐他汀对急性冠脉综合征患者CD4^+ CD25^+ CD127^- T细胞的影响[J].微循环学杂志,2009,19(4):27-28. 被引量:1
-
9诸晓枫,李红莉.IL-18、IL-10及其比值与冠状动脉粥样硬化斑块易损性研究进展[J].现代生物医学进展,2009,9(22):4387-4389. 被引量:11
-
10陈海,袁莉,方玲,魏达友,倪福文.阿托伐他汀与银杏叶制剂联合应用对颈动脉粥样硬化斑块与血脂的影响[J].中国医药,2010,5(3):220-222. 被引量:14
-
1王传英.急性心肌梗死早期应用阿托伐他汀治疗的疗效探讨[J].中国保健营养(下半月),2012,0(4):1012-1013.
-
2吴辉,刘晓方.阿托伐他汀短期治疗慢性心力衰竭的临床观察[J].实用心脑肺血管病杂志,2006,14(11):877-879. 被引量:2
-
3张云.辛伐他汀治疗原发性高血压223例疗效观察[J].山东医药,2007,47(7):48-48.
-
4张念,万勇.通心络胶囊对肺源性心脏病患者血液流变性及D-二聚体水平的影响[J].中国中医急症,2009,18(12):1984-1984. 被引量:3
-
5黄凤萍,石文.洛伐他汀调脂治疗对不稳定型心绞痛的临床疗效[J].广西医学,2006,28(4):583-584. 被引量:1
-
6孙会,王君库,唐天伟.氟伐他汀辅助治疗急性心肌梗死疗效观察[J].中国煤炭工业医学杂志,2008,11(11):1741-1741.
-
7郭毅,巫振欧.流行性出血热血清中的平滑肌抗体及临床意义[J].湖北医学院学报,1990,11(2):132-133.
-
8陈维杰,魏亚芬.辛伐他汀对非血脂异常冠脉综合征患者的疗效观察[J].中国急救医学,2005,25(5):387-387.
-
9孙文,谢春毅.丹红注射液治疗冠心病心绞痛临床观察[J].西部中医药,2014,27(3):5-6. 被引量:12
-
10唐艳芬,高想,尤菊松,孙建,章匀,朱金凤.辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压疗效观察[J].实用医学杂志,2010,26(22):4200-4202. 被引量:26