摘要
目的观察短期应用阿托伐他汀对慢性心力衰竭(CHF)患者心功能、血清肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的影响。方法选择50例CHF患者随机分成治疗组27例和对照组23例。所有CHF患者均给予常规治疗,治疗组在此基础上加用阿托伐他汀10mg/次,1次/d,晚餐后顿服,治疗4周。治疗前、后分别测量左室射血分数(LVEF)、TNF-α、IL-6和血脂水平。结果两组患者治疗前、后LVEF、TNF-α、IL-6间差异均有显著性意义(P<0·01);两组患者治疗前后差异亦均有显著性意义(P<0·05);治疗组患者治疗前、后TC、TG、LDL-C间差异均有显著性意义(P<0·01);两组患者治疗后TC、LDL-C间差异亦均有显著性意义(P<0·05)。结论短期应用阿托伐他汀可以降低CHF患者的TNF-α和IL-6水平,改善心功能,其作用机制考虑可能与他汀类药物的非调脂作用有关。
Objective To investigate the effects of short -term atorvastatin on cardiac function and serum levels of tumor necrosis factor-α （TNF-α） and interleukin- 6 （IL- 6） in patients with chronic congestive heart failure （CHF）. Methods Fifty patients with CHF were randomly divided into two groups： conventionul therapy group （ n = 23） and atorvastatin group （n = 27）. All patients with CHF were treated by conventional therapy： angiotensin converting enzyme inhibitior or angiotensin Ⅱ receptor blocks, α -adrenoceptor antagonists, diuretics, digoxin, et al. The atorvastatin group plus atorvastatin 10mg, quaquc nncte for four weeks. Before and after treatment, the left ventricular ejection fraction （LVEF） were measured by ultrasonic cardiography and serum lipids, TNF -α and IL -6 were measured by radioimmunoassay （RIA）. Results After four weeks, the serum levels of TNF - α and IL - 6 were significantly lower in the atorvastatin group than those in the eonventionul therapy group （ P 〈0.01）. This corresponded with improved LVEF in the atorvastatin group （ P 〈0. 05）. Conclusion Short -term atorvastatin therapy can improve cardiac function and decrease TNF- α and IL-6 in patients with CHF. It may be relevant to anti - inflammatory effect of the statins partly.
出处
《实用心脑肺血管病杂志》
2006年第11期877-879,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
