摘要
目的研究豚鼠耳后给药、全身给药后乙状窦及体循环血浆中复方倍他米松药物代谢动力学特征,探讨耳后给药的可能作用途径。方法以复方倍他米松注射液(1 ml)为药物示踪剂,将豚鼠随机分成耳后注射(耳后组)及肌肉注射(肌注组)两组,每组50只,分别采集耳后及全身给药后0.5、1、1.5、2、3、5、7小时及1、2、4周双侧乙状窦及体循环血液,用高效液相色谱法分别检测其中的药物浓度。结果①乙状窦血:耳后组注射同侧乙状窦血中峰浓度(Cmax)最高,为对侧的2.56倍,为肌注组的3.03倍;耳后组注射同侧乙状窦血中药时曲线下面积(area under the ct curve,AUC)最高,为对侧的2.41倍,为肌注组的2.93倍。②体循环血:耳后给药体循环血中的药物浓度一直维持在较低的水平,耳后组Cmax为肌注组的0.13倍,耳后组AUC为肌注组的0.32倍。结论耳后给药药物可能通过局部静脉回流在乙状窦中达到较高峰值,且持续时间相对较长,而在体循环血中一直保持着较低的浓度水平。
Objective To investigate plasma pharmacokinetics profiles of compound betameth in guinea pig after postaurieal and systemic administrations,and to explore the possible pathway for postaurical injection.Methods 1 ml compound-betameth was injected postaurieally and intramuscularly into the guinea pig.Blood were samples obtained 0.5,1,1.5,2,3,5,7 h and 1,2,4 w after the administration of contralateral sigmoid sinus blood and circulatory blood respectively.High performance liquid chromatography was used to dectet compound betameth in the samples.Results ①Sigmoid sinus blood： Betamethasone could reach a higher concentration in sigmoid sinus blood following postaurieal administration.The Cmax（peak concentration） in sigmoid sinus of postaurieal group was 2.56 and 3.03 higher than those in the contralateral and the systemic group.The AUC（（area under the ct curve） was 2.41 and 2.93 higher.②Circulatory blood： Betamethasone had been a lower concentration in circulatory blood following postaurieal administration.The Cmax and AUC in postaurieal group were 0.13 and 0.32 higher than systemic group.Conclusion The postaurieal injection reached a higher concentration of drugs in the sigmoid sinus blood,and remained a lower concentration in circulatory blood.
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2009年第4期354-357,共4页
Journal of Audiology and Speech Pathology
基金
国家自然科学基金主任专项基金(30840090)
国家十一五攻关资助项目(2007AA02Z498)
关键词
复方倍他米松
给药方式
药代动力学
Compound betameth
Administration route
Pharmacokinetics
