摘要
目的:探讨白细胞介素-18(IL-18)和肿瘤坏死因子-α与特发性血小板减少性紫癜(TIP)发病的关系,研究其在ITP发病中的作用及临床意义。方法:应用酶联免疫吸附法(ELISA)测定32例ITP患儿和17例正常儿童血清IL-18、TNF-α含量。结果:TIP组血清IL-18、TNF-α含量均显著高于正常对照组(均P<0.05),IL-18含量与TNF-α呈显著性正相关(rs=0.539,P<0.05),与血小板数量呈显著性负相关(rs=-0.548,P<0.05)。结论:IL-18、TNF-α与TTP发病密切相关。
Objective ： To exploer the rationship between interleukin - 18 （ IL - 18 ） , TNF - α level and pathogenesis of idiopathic thrombocytopenic purpura （ITP） , and study the efect and clinical significance of IL - 18, TNF - α in ITP. Methods： The plasma IL - 18 and TNF - α in 32 ITP patients and 17 normal contorls were detected by enzyme linked immunosorbent assay （ELISA）. Results： The serum IL- 18, TNF-α in ITP patients were all elevated . There were significant difference between ITP group and normol group （ P 〈 0 . 05 ）. The level of IL - 18 was positive correlated to TNF -α and negative correlated to the platelet quantity（ P 〈 0.05 ）in ITP patients. Conclusion ： IL - 18,TNF - α may be closely associated with the pathogenesis of ITP.
出处
《河南医学研究》
CAS
2009年第2期105-106,共2页
Henan Medical Research
