摘要
目的:探讨IL-10、IL-18和IFN-γ水平与系统性红斑狼疮(SLE)发病的关系。方法:采用ELISA法检测45例SLE患者和40例正常对照组血浆IL-10、IL-18和IFN-γ的水平。结果:SLE组IL-l0(76.24±8.37)pg/ml、IL-18(251.32±71.28)pg/ml较正常对照组IL-10(17.92±6.32)pg/ml、IL-18(191.41±64.25)pg/ml差异有统计学意义(p<0.01),且SLE活动组IL-10(95.76±11.89)pg/ml、IL-18(394.24±138.16)pg/ml与非活动组IL-10(41.35±13.27)pg/ml、IL-18(214.80±69.21)pg/ml之间比较差异有统计学意义(p<0.01);IFN-γ在各组间差异无统计学意义(p>0.05);SLE组IL-10与IL-18呈正相关(r=0.521,p<0.01),而IL-10与IFN-γ以及IL-18与IFN-γ间无相关性。结论:IL-10、IL-18水平与疾病活动性有关,可作为判断疾病疗效的监测指标。IFN-γ在各组间无明显变化,可能与IL-10与IL-l8等细胞因子之间的拮抗作用有关。
OBJECTIVE： To investigate the correlation and change of serum IL - 10 、 IL-18 and IFN -γ）, in systemic lupus erythematosus （SLE）. METHOD： the levels of IL- 10, IL- 18, IFN -γ from 45 patients with SLE and 40 normal control were determined with sandwich ELISA. RESULTS： the levels of IL - 10 （76. 24± 8.37 pg/ml） and IL - 18 （251.32 ± 71.28pg/ml） in SLE were signfieant higher than that of the control group （ p 〈 0. 01 ）. And there was a noticeable difference between active SLE patient （IL- 10; 95.76 ± 11.89pg/ml and IL - 18; 394. 24 ± 138.16pg/ml） and inactive patients （IL - 10; 41.35 ± 13.27pg/ml and IL -- 18 ; 214. 80 ±69. 21pg/ml） （ p 〈0. 01）. the level of IFN -γ）, in active SLE and inactive SLE and control group were no significantly difference （ p 〉 0. 05）. In addition , there was a significant positive correlation between IL - 10 and IL - 18 in SLE （ p 〈 0. 01 ）, while no correlation in other groups （ p 〉 0. 05）. CONCLUSION： The levels of IL - 10 and IL - 18 are increased in active patients with SLE and may play a significant role in the curative effect of SLE. There were no significant differences between SLE group and control group in level of IFN - γ. It may be related to the competition between IL - 10 and IL - 18.
出处
《九江医学》
2009年第2期6-8,共3页
Jiujiang Medical Journal
