摘要
目的检测冠心病患者血浆白细胞介素-10(IL-10)和肿瘤坏死因子-α(TNF-α)水平变化,探讨急性冠状动脉综合症促炎和抗炎平衡失调是导致斑块不稳定的主要因素。方法用双抗体夹心ELISA法对66例冠心病患者和20例正常对照者血浆IL-10、TNF-α和TNF-α/IL-10水平变化进行研究,同时对23例急性冠状动脉综合症(ACS)患者常规治疗2周后上述3项指标变化进行分析。结果稳定型心绞痛(SAP)组患者和ACS组患者血浆TNF-α水平明显高于正常对照组(P<0.05),尤以ACS组升高更明显;SAP和ACS组患者血浆IL-10水平高于正常对照组(P<0.05),ACS组升高更明显;TNF-α/IL-10比值ACS组最高,SAP组次之,正常对照组最低;ACS组治疗前后上述3项指标比较差异有统计学意义(P<0.05)。结论冠心病患者体内存在促炎和抗炎机制的平衡失调,TNF-α/IL-10可作为冠心病发展的预测指标。
Objective To investigate the changes of plasma levels of TNF-α,IL-10 and TNF-α/IL-10 in patients with coronary heart disease（ CHD）, and the effect of imbalance between inflammatory and anti-inflammatory cytokins on unstable plaque. Methods Plasma TNF-α,IL-10 and TNF-α/IL-10 in 66 CHD patients and 20 controls were detected by ELISA. A second measurement of these indexes was performed in 23 ACS patients after two weeks treatment. Results The CHD patients, especially those with ACS had significantly high levels of TNF-α and IL-10 in comparison with the controls. TNF-α/IL-10 ratio was markedly in- creased in CHD patients, especially in ACS patients. In ACS patients, there were significant differences between the levels of the three indexes before and after treatment. Conclusions CHD patients , especially ACS patients have an imbalance between in- flammatory and anti-inflammatory ,TNF-α/IL-10 ratio possibly can be regarded as index of development of coronary heart disease.
出处
《中华全科医学》
2008年第9期913-914,共2页
Chinese Journal of General Practice
