摘要
目的探讨耐甲氧西林金黄色葡萄球菌(MRSA)的耐药性及流行趋势,评价痰热清注射液联合万古霉素治疗MRSA感染性肺炎的疗效。方法对2001-2007年某医院痰标本微生物学培养资料进行分析,了解金黄色葡萄球菌菌株构成,MRSA的流行趋势及其耐药性,采用随机对照,将100例MRSA感染性肺炎患者平均分为2组,分别予万古霉素、痰热清注射液+万古霉素注射液治疗。结果3244株金黄色葡萄球菌中,MRSA3082株,甲氧西林敏感金黄色葡萄球菌(MSSA)162株,MRSA分离率有随时间增加的趋势(P<0.05);78.07%MRSA来自医院感染;MRSA对万古霉素耐药率为0,对其他抗菌药物广泛耐药,与MSSA耐药率比较差异有统计学意义(P<0.01);中药痰热清+万古霉素联合治疗MRSA感染性肺炎疗效明显优于单纯万古霉素(P<0.01)。结论MRSA是院内肺部感染的重要致病菌;除万古霉素外,MRSA对其他抗菌药物广泛耐药,中药痰热清与万古霉素联合治疗MRSA感染性肺炎具有良好疗效。
OBJECTIVE To investigate （meticillin-resistant Staphylococcus aureus MRSA） the antibiotics resistance and curative effect of herbal Tanreqing-injection combined with vancomycin in the treatment of MRSA pneumonia. METHODS All data of microbiology about sputum culture between 2001--2007 were statistically analyzed with a retrospective method in a hospital, in order to understand the MRSA prevalence trends and their resistance. From 100 cases of MRSA pneumonia, 50 cases were treated by vancomycin alone, another 50 cases were treated by Tanreqing injection plus vancomycin. RESULTS There were 3082 MRSA strains and 162 （meticillin-sensitive S. aureus MSSA） strains in 3244 S. aureus strains; nosocomial infection cases accounted for 78. 07% in MRSA-positive sputum samples~ MRSA wasn＇t resistant to vancomycin, but resistant to other antibiotics. Resistance rates had a significant difference between MRSA and MSSA （P〈 0. 01）. The treatment efficacy of Tanreqing injection plus vancomycin injection was superior to vancomycin therapy alone （P〈0.01）. CONCLUSIONS MRSA is important pathogen for nosocomial infection, MRSA show resistance to many kinds of antibiotics except vancomycin. The vancomycin combined with Tanreqing-injection has a better effect in the treatment of MRSA pneumonia.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第14期1861-1863,共3页
Chinese Journal of Nosocomiology
