摘要
目的:探讨痰热清注射液治疗慢性阻塞性肺疾病(COPD)急性加重期的临床疗效及细胞因子水平的变化。方法:选择87例COPD急性加重期患者,随机分为两组,治疗组44例用痰热清注射液20mL加入5%葡萄糖生理盐水500mL中静脉滴注,每日1次。对照组炎琥宁注射液0.4g加入5%葡萄糖生理盐水250m静脉滴注,每日1次,2组疗程均为2周。分别于治疗前后观察临床疗效和TL-10,TNF-α,MPO的变化。结果:治疗组总有效率94.31%,对照组总有效率83.75%。差异有显著性(P<0.01)。两组IL-10水平均较健康组低(P<0.01)。而TNF-α及MPO较健康组高(P<0.01)。治疗后治疗组TNF-α,MPO水平与对照组比明显降低(P<0.01),IL-10与对照组比明显增高,差异有显著性(P<0.01)。结论:痰热清治疗COPD急性加重期效果显著,无明显毒性作用,临床使用安全。且能有效地抑制上述细胞因子的释放,是治疗COPD急性加重期的重要作用之一。
Objective:To make a study of the clinical effect on the treatment of chronic obstructive pulmonary disease in acute aggravated stage with Tanreqing Injection and the changes of the cell factor level. Method:Eighty-seven cases of COPD patients in acute aggravated stage were chosen and divided into two groups at random. Forty-four cases in treatment group were given intravenous drip of Tanreqing(20 mL) with 5% G/NS(500 mL) once a day. Forty-three cases in control group were given intravenous drip Yanhuning in...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第1期104-106,共3页
China Journal of Chinese Materia Medica
