摘要
目的:了解抑郁症患者空腹血糖、皮质醇的水平及其与精神症状的关系。方法:以68例近期未服抗抑郁药的抑郁症患者为研究对象,了解他们简易体质参数,患者精神症状采用17项汉密顿抑郁量表和汉密顿焦虑量表进行评定;对患者精神刺激的定性及定量用生活事件量表。测定其空腹血糖、皮质醇的水平,并与40例健康者组成的对照组进行比较。结果:抑郁症组的空腹血糖、皮质醇值显著高于对照组(P<0.01);相关分析发现,抑郁症患者生活事件量表总分与空腹血糖、皮质醇水平正相关(P<0.01)。结论:抑郁症患者存在一定的糖代谢异常,与患者长期精神刺激明显有关。所以,临床医师应对抑郁症患者的血糖、皮质醇水平进行监测,以便早发现早治疗,早期心理干预也是非常重要的。
Objective： To investigate the fasting glucose and cortisol levels in major depression patients and their relations to psychiatric symptom. Methods： Sixty-eight major depression patients in hospital without taking antidepressant drugs at least four weeks were examined, and the results of HAMD17, HAMA14, life event scale （LES）, the height, body weight, waistline, hip circumference, fasting blood glucose （FBS）, and cortisol level were recorded and compared with those in 40 normal subjects. Results： Depressive patients had significantly higher level of FBS and cortisol （P〈0.01）. The LES total scores was correlated positively to their level of FBS and cortisol （both P〈0.01）. Conclusion： There are some disorders in glucose metabolism of depressive patients in relation to chronic stress. Clinician shoud monitor the FBS and cortisol level to ensure early detection and treatment, and mental intervention in earlier period is also necessary.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第4期515-517,529,共4页
Medical Journal of Wuhan University
关键词
抑郁症
空腹血糖
皮质醇
Major Depression
Fasting Blood Glucose
Cortisol
