摘要
目的:探讨亚急性甲状腺炎患者甲状腺功能和血清胰岛素样生长因子1(IGF-1)水平的变化。方法:采用放射免疫分析(RIA)检测28例经抗生素、肾上腺皮质激素和甲状腺素片治疗前后亚急性甲状腺炎患者和28名健康人(对照组)血清IGF-1和甲状腺激素水平。结果:治疗前亚急性甲状腺炎血清IGF-1水平(714.02±309.74)mIU/mL明显高于对照组(211.13±39.85)mIU/mL,差异有显著性(P<0.01);亚急性甲状腺炎治疗后,患者血清IGF-1水平(91.18±30.83)mIU/mL明显低于治疗前(P<0.01),与对照组比较差异有显著性(P<0.01)。结论:亚急性甲状腺炎患者治疗前血清IGF-1和甲状腺激素水平明显升高,IGF-1的正常调节受到后者变化的影响;且在治疗后期IGF-1水平下降有助于甲状腺功能的恢复。
Objective：To study the changes of serum insulin-like growth factor-1 （IGF-1） and thyroid hormone levels in Subacute thyroiditis. Methods：The serum IGF-1 level was determined with radio-immunologic assay（RIA） in 28 cases before and after therapy with antibiotic,adrenocortical hormone and roxine in primary Subacute thyroiditis and 28 normal controls. Results：The serum IGF-1 level （714.02±309. 75）mIU/mL in Subacute thyroiditis was significantly higher than that of IGF-1 level （211.13±39.85）mlU/mL in controls（P 〈0. 01）. The serum IGF-1 level （91.18±30. 83）mlU/mL in Subacute thyroiditis patients after treatment was significantly lower than that before treatment （P〈0.01） and there was also difference compared with that of controls（P〈0. 01）. Conclusion.. The levels of serum IGF-1 and thyroid hormone in Subacute thyroiditis markedly＇increase and the normal regulation of IGF-1 may be influenced significantly by changes of thyroid hormone levels; and the levels of serum IGF-1 decreasing help to resume thyroid function after treatment.
出处
《河北北方学院学报（医学版）》
2009年第3期51-53,共3页
Journal of Hebei North University:Medical Edition
