摘要
目的探讨高同型半胱氨酸血症(Hhcy)与颈内动脉系统短暂性脑缺血发作(TIA)患者责任血管病变程度的关系,进而为动脉硬化及TIA患者的治疗提供新的理论依据。方法测定119例颈内动脉系统TIA患者和52例健康对照者空腹血浆同型半胱氨酸(Hcy),以经颅多普勒超声(TCD)检查对患者责任血管状况进行评价,并以对照组Hcy检测结果将患者分为Hhcy组和非Hhcy组进行研究。结果Hhcy组患者责任血管病变较非Hhcy组明显,差异具有统计学意义(P=0.002),经Ordinal回归分析,显示Hhcy是TIA患者责任血管病变的独立危险因素(P<0.01),优势比为4.707(95%CI:1.992-11.123)。结论Hhcy与TIA患者责任血管病变密切相关。
Objective To explore the possible relationship of hyperhomocysteinemia and the lesion degree of relative arteries in patients with transient isehemic attacks （TIA） of internal carotid artery system in hope for finding a new theoretical evidence for the therapy of artery atherosclerosis and TIA. Methods We determined the free plasma homocysteine （Hcy） of 119 patients with internal carotid artery system TIA and 52 age-and gender-matched healthy controls by high-performance liquid chromatography,and assessed the relative arteries of patients by transcranial Doppler sonography. And we divided the patients into hyperhomocysteinemia （Hhcy） group and non-hyperhomocysteinemia （Nhhcy） group according to the outcomes,then we researched the lesion degree of relative arteries of the groups. Results There was statistical deference in the lesion degree of relative arteries between Hhcy and Nhhcy group. By Ordinal regression analysis, we found that Hhcy was an independent risk factor for the artery lesion of TIA patients （P 〈 0.01 ; OR = 4.707 ;95 % CI ： 1. 992-11. 123 ）. Conclusion Hhcy might be closely correlated with the relative artery lesion in TIA patients.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2009年第3期307-309,共3页
Journal of Apoplexy and Nervous Diseases
