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瘢痕疙瘩不同部位成纤维细胞周期蛋白D1的表达 被引量：1

Cyclin D1 expression of fibroblasts in different areas of keloid
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摘要 目的了解瘢痕疙瘩周边和中央部成纤维细胞中Cyclin D1表达的差异。方法应用免疫组织化SP法检测瘢痕疙瘩成纤维细胞中Cyclin D1表达。结果在瘢痕疙瘩周边部成纤维细胞存在Cyclin D1呈高表达,而在中央部Cy-clin D1表达较低。结论瘢痕疙瘩周边部成纤维细胞中Cyclin D1呈高表达,可能是瘢痕疙瘩异常增生并呈侵润性生长的原因之一。 Objective To study cyclin D1 expression of fibroblasts in the peripheral and central regions of keloid. Methods Cyclin DI expression of fibroblasts in keloid was detected by SP method of immunohistochemistry. Results Expression of cyclin D1 in peripheral region was superior to that in central one. Conclusion Cyclin D1 overexpression of fibroblasts in peripheral area of keloid could contribute to the hyperproliferation and invasive growth.
作者 梁大宁
机构地区 广东东莞常平医院
出处 《广东医学院学报》 2009年第3期237-238,244,共3页 Journal of Guangdong Medical College
关键词 瘢痕疙瘩 细胞周期蛋白D1 细胞周期 keloid cyclin DI cell cycle
分类号 R619.6 [医药卫生—外科学]
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参考文献9

二级参考文献46

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共引文献15

同被引文献20

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广东医学院学报
2009年 第3期

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