摘要
目的：研究刺激延髓网状结构对脑血流量及颅内压的影响。方法：电解毁损家兔下丘脑背内侧核和中脑网状结构基础上电刺激延髓网状结构，毁损或刺激前静脉注射地塞米松５ｍｇ／ｋｇ，观察颅内压、脑血流量和脑含水量变化。结果：刺激单侧延髓网状结构后颅内压和脑血流量呈短暂可逆性增加，脑含水量无变化；强刺激双侧延髓网状结构后颅内压进行性上升，脑血流量先增加后减少，脑含水量增加。后者应用地塞米松后颅内压增高、脑血流量减少和脑水肿均减轻。结论：破坏下丘脑和中脑以及刺激延髓都将导致大脑血管紧张性降低。大剂量地塞米松可减轻脑水肿而防止颅内压进行性上升。
Objective: To study the effect of stimulation of the medullary reticular formation (MORF) on cerebral blood flow (CBF) and intracranial pressure (ICP). Methods: ICP, CBF, and brain water content (BWC) were measured after electrical stimulation of MORF following electrolytical destruction of the dorsomedial nuecleus of the hypothalamus (DMH) and the midbrain reticular formation (MBRF) in rabbits. During the experiment, a highdose dexamethasone (5mg/kg) was iv. administered. Results: Transient and reversible increases in ICP and CBF were found after unilateral stimulation of MORF without change of BWC; while a progressive and irreversible increase in ICP, an ultraearly increase and an early reduction in CBF as well as early brain edema were found after bilateral stimulation of MORF. Dexamethasone ameliorated progressively increased ICP, decreased CBF and brain edema caused by the bilateral stimulation of MORF. Conclusion: These findings indicate that lesions of DMH or MBRF and stimulation of MORF both result in loss of cerebral vasomotor tonus. Dexamethasone may prevent brain edema from progressive increasing of ICP.
出处
《中华神经外科杂志》
CSCD
北大核心
1998年第4期219-221,共3页
Chinese Journal of Neurosurgery
基金
江苏省科委基金
关键词
延髓网状结构
脑血流量
颅内压
地塞米松
脑水肿
Medullary reticular formation Cerebral blood flow Intracranial pressureDexamethasone
