摘要
目的评价肾小球滤过率(glomerular filter rate,GFR)评估方程在少数民族和汉族慢性肾脏病(chro-nic kidney d isease,CKD)患者中的适用性。方法选择174例慢性肾脏病患者(包括少数民族和汉族患者),将Cock-croft-Gault方程、MDRD 7方程、简化MDRD方程计算的GFR值用体表面积(BSA)标准化,与BSA标准化的99mTc-DTPA测得的GFR在不同CKD分期进行比较。结果方程计算的GFR(cGFR、7GFR、aGFR)与99mTc-GFR(sGFR)分别在少数民族及汉族具有显著的相关性,相关性较好的依次为MDRD 7、简化MDRD、Cockcroft-Gault方程;Roc曲线下的面积也表明MDRD 7方程诊断的敏感性最好,简化MDRD次之。但是7GFR、aGFRc、cGFR与99mTc-GFR差异均有显著意义(P<0.01)。结论上述方程用于我国少数民族和汉族CKD患者时,应对三个方程进行修正。
Objective To estimate the applicability of GFR （glomerular filter rate） equations in minority and Han nationality with chronic kidney disease （CKD）. Methods 174 patients （included Han nationality and minority） with CKD were selected. GFR estimated with MDRD seven equation, abbreviated MDRD equation and Cockcreft - Gault （CG） equation were compared with ^99mTc - DTPA plasma clearance （sGFR） in different stages of CKD. The GFRs were standardized by body surface area. Results The GFRs of the three equations were significantly correlated with sGFR. Among them, MDRD seven equation, seemed to be the best for GFR estimation, aMDRD equation was the second. Furthermore, the mean area under Roc curve was the similar result. There Was significant difference between GFR estimated with three equations and sGFR in different stage of CKD. Conclusion The three equations for estimation of GFR should be amended when applying to Han Nationality with CKD.
出处
《实用心脑肺血管病杂志》
2009年第6期455-457,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
少数民族
汉族
肾疾病
肾小球滤过率
Minority groups
Han hattionality
Kidney diseases
Glomerular filtration rate
