摘要
目的探究肾小球滤过率(glomerular filterrate,GFR)评估方程在少数民族和汉族慢性肾脏病(chronic kidneydisease,CKD)患者中的临床研究.方法选择174例慢性肾脏病患者(包括少数民族和汉族患者),将Cockcroft-Gault方程、MDRD7方程和简化MDRD方程计算的GFR值用体表面积(BSA)标准化,与BSA标准化的99mTc-DTPA测得的GFR在不同CKD分期进行比较.结果方程计算的GFR(cGFR、7GFR、aGFR)与99mTc-GFR(sGFR)分别在少数民族、汉族及总的慢性肾脏病患者均具有显著的相关性,相关性较好的依次为MDRD7、简化MDRD、Cockcroft-Gault方程;Roc曲线下的面积也表明MDRD7方程诊断的敏感性最好,aMDRD次之.但是7GFR、aGFRc、cGFR的计算值与99mTc-GFR在不同的CKD分期差异均有显著意义(P<0.01).结论上述方程用于我国少数民族和汉族CKD患者时,应对三个方程进行修正.
Objective To explore the application of GFR （glomerular filter rate） equations in patients with chronic kidney disease （CKD）. Methods 174 patients （included Han nationality and minority） with CKD were selected. GFRs estimated with MDRD seven equation, abbreviated MDRD equation and Cockcroft-Gauh （CG） equation were compared with 99mTc-DTPA plasma clearance （sGFR） in different stages of CKD. The GFRs were standardized by body surface area. Results The GFRs of the three equations were significantly correlated with sGFR. Among them, MDRD seven equation, seemed to be the best for GFR estimation, aMDRD equation was the second. Furthermore, the mean area under Roc curve was the similar result. There were significant differences between GFRs estimated with three equations and sGFR in different stage of CKD. Conclusion The three equations for estimation of GFR should be amended when applying to patients of minority and Han nationality with CKD.
出处
《昆明医学院学报》
2009年第6期105-109,共5页
Journal of Kunming Medical College
