摘要
目的探讨联合检测癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)和细胞角蛋白19片段抗原(CYFRA21-1)在肺癌诊断中的价值。方法583例肺部疾病患者(其中肺癌508例,肺部良性病变75例),采用罗氏电化学发光免疫系统检测其血清CEA、CYFRA21-1、NSE肿瘤标志物水平。结果肺癌患者血清肿瘤标志物均高于肺良性病变中(P<0.05),敏感性分别为CEA 48.6%(247/508)、CYFRA21-155.3%(281/508)和NSE 53.5%(272/508),联合检测敏感性为82.9%(421/508)。结论CEA、NSE和CY-FRA21-1对肺癌诊断中有一定价值。联合检测对各类型肺癌有较高的敏感性和特异性。
Objective To study diagnostic value of simultaneous detection of three tumor markers （CEA, NSE, CYFRA21-1） in patients with lung cancer. Methods Blood of 583 patients with pulmonary diseases （508 patients with pulmonary careinoma,75 patients with pulmonary benign lesion） was collected, and the contents of CEA, NSE and CYFRA21-1 in the sera were measured by ELECSYS2010. Results The concentra- tions of the three tumor markers in the cancer patients group were higher than those in benign lung diseases group （P 〈0. 05）. The sensitivity rates were CEA 48. 6% （247/508）, CYFRA21-1 55. 3% （281/508） and NSE 53. 5% （272/508）. However, the sensitivity rate of combined detection achieved 82. 9% （421/508）. Conclusion CEA, NSE and CYFRA21-1 have certain value for the diagnosis of the pulmonary carcinoma, simultaneous detection can signifieandy improve the sensitivity and specificity for diagnosis of lung cancer.
出处
《中国肿瘤临床与康复》
2009年第3期214-215,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肺肿瘤
肿瘤标志物
诊断
Lung neoplasms
Tumor marker
Diagnosis
