摘要
目的 促进肿瘤诊断试验评价质量的提高。 方法 采用整群抽样调查了《中华肿瘤杂志》90年代刊载的临床诊断试验论著。 结果 在调查的 2 3篇论著中 ,免疫学诊断试验占比重最大 ,为 39 1% (9/2 3) ,其次为生化学、影像学检查 ,分别占 17 4% (4 /2 3)、13 0 % (3/2 3) ;金标准明确可靠者占 82 6 % (19/2 3) ,正确计算灵敏度及特异度者占 6 0 9% (14/2 3) ,采用盲法者占 39 1% (9/2 3) ;符合全部 7条方法学标准者仅为 4 3 % (1/2 3) ,符合 7条方法学标准中 4条以上者为 5 6 5 % (13/2 3) ,仅符合 1条方法学标准者为 8 7% (2 /2 3)。 结论 诊断试验评价的方法学标准受到了一定程度重视 ,肿瘤诊断试验论著质量有待提高与完善。
Objective To improve the quality of papers on clinical diagnostic tests. Methods[WT5”BZ] Articles of diagnostic tests published in the Chinese Journal of Oncology in the year 1990 were surveyed by cluster sampling method. Results[WT5”BZ] In the 23 articles surveyed, immunoassays constituted the largest category, accounting for 39.1% (9/23), followed by biochemical markers and radiological tests, accounting for 17.4%(4/23) and 13.0%(3/23),respectively. Of the 23 articles, 19 (82.6%) employed a well-defined “gold standard”,14 (60.9%) correctly calculated sensitivity and specificity. The interpretation of the test was stated to be “blind” in only 39.1%(9/32). In only one paper were all the seven methodologic criteria adhered. Less than 60% of the articles followed more than four of the seven methodologic criteria, and in 2 articles only one of the criteria was met with. Conclusion Although due attention has been paid to the methodologic criteria of assessing diagnostic tests, the quality of the articles surveyed needs to be improved.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第1期28-30,共3页
Chinese Journal of Oncology
