摘要
目的通过家猪实验，研究消融阻隔气囊在肝脏射频消融治疗中的保护作用。方法5只猪全麻后在CT引导下行射频消融治疗，针对消融阻隔气囊的保护作用行随机对照实验研究。每只猪均取两个治疗区，实验区加用消融阻隔气囊保护，对照区不用阻隔气囊。术后3～4d处死猪，观察组织坏死病理变化并测量坏死组织面积：结果实验组和对照组各有5个治疗区，实验组消融时间为（18．2±2．6）min，肝坏死组织的最大直径为（4．9±0．5）cm；对照组消融时间为（16．0±1．8）min，肝组织坏死最大直径为（4．6±0．6）cm，两组治疗时间和肝组织坏死最大直径差异无统计学意义（P〉0．05）。实验组无膈肌损伤，对照组膈肌均有热损伤，瞩肌损伤面积平均（5．2±2．0）cm^2，两例出现穿孔。结论消融阻隔气囊可在行射频消融时有效保护邻近器官，减少热损伤并发症.
Objective To evaluate protective effect of using ablation-separating balloon during liver radiofrequence ablation（RFA） in swine. Methods Five swines were received liver RFA under real-time CT guidance after general anaesthesia, A randomized control trial about protective effect of using ablation-separating balloon was carried out. Each swine received twice RFA in its liver adjacent to diaphragm. Experimental region was protected with ablation-seperating balloon, and control region was treated without protection. The swines were sacrificed 3 to 4 d after RFA. Pathologic changes were observed and liver necrosis area was measured. Results Every, group had 5 regions of RFA. Average duration of RFA in experimental group was （18.2±2.6） rain, and that in control group was （16.0±1.8） rain. The maximum diameter of liver necrosis in experimental group was （4.9±0.5 ） cm, and that in control group was （4.6±0.6） cm. The average duration of RFA and maximum diameter of liver neocrosis had no significant difference （P〉0.05）. There was no diaphragmatic thermal injury in experimental group, but diaphragmatic thermal injury was observed in all the swines in control group. The average injury area of diaphragm was （5.2±2.0） cm^2, and perforation of diaphragm took place in two swines. Conclusion The ablation-seperating balloon can effectively protect adjacent tissue to target organ of RFA, and reduce complications of thermal injury.
出处
《中华生物医学工程杂志》
CAS
2009年第1期61-64,共4页
Chinese Journal of Biomedical Engineering
关键词
消融术
射频
术后并发症
气囊
热损伤
膈肌
Ablation, radiofrequency
Postoperative complications
Balloon
Thermalinjuly
Diaphragm
