摘要
方法：从小麦麸中提取膳食纤维素，混合可溶性纤维海藻酸钠，制成膳食纤维冲剂，观察对大鼠血脂紊乱的预防和治疗效果及对人体高血脂、高血糖和习惯性便秘的治疗效果。结果：１．膳食纤维冲剂（ＤＦＧ）可明显降低高血脂大鼠血中胆固醇（ＴＣ）、甘油三酯（ＴＧ）和低密度脂蛋白胆固醇（ＬＤＬ－Ｃ），并可预防高脂饲料大鼠ＴＣ、ＴＧ、ＬＤＬ－Ｃ的增高，正常大鼠血糖无明显变化，排便显著增加。２．患者每日服用５ｇ×３次ＤＦＧ（相当于１０ｇ纤维素），可缓解习惯性便秘，有效率为１００％；可显著降低高血脂患者的ＴＣ和ＬＤＬ－Ｃ，总有效率为１００％；Ⅰ、Ⅱ型糖尿病患者空腹血糖值下降显著，总有效率为８９．９％。ＤＦＧ小鼠最大耐受量试验为５ｇ／ｋｇｂｗ以上。人体每日服用１５ｇＤＦＧ无不良反应。
A dietary fiber granule, consisting of refined wheat bran and sodium aliginate was developed. Study was conducted to observe its preventive and curative effects on the disturbances of blood lipid in rat and curative effects on human hyperlipemia, hyperglycemia and habitual constipation. The results showed that DFG could significantly decrease TC, TG and LDL C in rats with high blood lipid; and prevent the increase of TC, TG and LDL C in rats fed with high fat diet. In normal rats, there was no obvious change of blood sugar, but the amount of defecation was increased. The effective rate of improving habitual constipation was 100% in patients taken 5g DFG, 3 times daily (equal to 10 fiber). The total effective rate of lowering TC and LDL C in patients with high blood lipid was 100%. The total effective rate of decresasing fasting blood sugar in patients with I or Ⅱ type of diabetes was 89.8%. The maximum tolerance of DFG in rats was 5g/kg bw. There was no side effect of DFG in patients taking 15g daily.
出处
《营养学报》
CAS
CSCD
北大核心
1998年第2期209-214,共6页
Acta Nutrimenta Sinica
基金
黑龙江省科技攻关项目
关键词
膳食纤维冲剂
疗效
血脂
血糖
便秘
dietary fiber blood lipid blood sugar constipation
