摘要
目的探讨无症状脑梗死(SBI)患者认知功能障碍及抑郁与事件相关电位(ERP)变化的关系。方法对68例SBI患者采用汉密尔顿抑郁(HAMD)量表、简易精神状态检查(MMSE)量表及ERP检查,并与55例非脑梗死患者(对照组)进行比较。结果SBI组中,31例(45.6%)HAMD≥17分(抑郁亚组),37例(54.4%)HAMD<17分(非抑郁亚组)。SBI组MMSE评分(17.1±1.8)较对照组(25.2±1.6)显著降低,认知功能障碍发生率(52.9%vs 12.7%)显著增高(均P<0.05);与对照组相比,SBI组P3潜伏期显著延长,波幅显著降低(均P<0.05)。SBI组中,抑郁亚组MMSE评分(14.9±1.2)较非抑郁亚组(21.6±2.6)显著降低,认知功能障碍发生率(93.6%vs 21.6%)显著增高,P3潜伏期明显延长和波幅明显降低(均P<0.05)。SBI抑郁亚组MMSE评分与P3潜伏期负相关,与波幅正相关(r=-0.537,r=0.529;均P<0.05)。结论SBI患者存在认知功能障碍,伴抑郁症状者认知功能障碍更显著。ERP检查可早期发现SBI患者的认知功能障碍及抑郁。
Objective To study the relationship between cognitive dysfunction and depression and event-related potential（ERP） in patients with silent brain infarction （SBI）. Methods 68 SBI patients were tested by the Hamilton Depression Rating Scale for Depression （ HAMD ） , scale of mini mental state examination （ MMSE ） and ERP; and the results were compared with those in 55 patients without cerebral infarction （control group）. Results In the SBI group, the HAM D score was ≥ 17 in 31 （45.6%）cases（ depression subgroup）and 〈 17 in 37 （54.4%） cases （no-depression subgroup）. The score of MMSE in SBI group（ 17.1 ± 1.8）was significantly lower than that in control group（25.2 ± 1.6） ;the rate of cognitive dysfunction was significantly higher（52.9% vs 12.7% ） （ all P 〈 0. 05 ）. Compared with control group, the P3 latent period was significantly longer and the P3 amplitude was significantly lower in SBI group（ all P 〈0. 05 ）. In SBI grouop, the score of MMSE in depression subgroup （ 14.9 ± 1.2） was significantly lower compared with no-depression subgroup （ 21.6 ± 2.6） ; the rate of cognitive dysfunction was higher（93.6% vs 21. 6% ）. Compared with no-depression subgroup, the P3 latent period was significantly longer and the amplitude was lower in depression subgroup（ all P 〈 0. 05 ）. The score of MMSE was the negative correlation with P3 latent period, and the positive correlation with P3 amplitude in SBI depression subgroup （ r = - 0. 537, r = 0. 529 ; all P 〈 0. 05 ）. Conclusions The SBI patients have cognitive dysfunction, and which is more notable in SBI patients combining depression. The ERP examination can find out cognitive dysfunction and depession at early stage in SBI patients.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第3期193-195,共3页
Journal of Clinical Neurology
关键词
无症状脑梗死
认知功能障碍
抑郁
事件相关电位
silent brain infarction
cognitive dysfunction
depression
event-related potential
