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干扰素诱导蛋白10与妊娠期高血压疾病 被引量：1

Interferon-γ Inducible Protein 10 and Hypertensive Disorder Complicating Pregnancy
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摘要 妊娠期高血压疾病是妊娠妇女和围生儿死亡的主要原因之一,迄今病因仍未明了。目前研究认为内皮细胞损伤、血管生成抑制和血管间炎症在其发病中起重要作用。干扰素诱导蛋白10(IP-10)属于CXC家族的趋化因子,能介导Th1型炎症反应和抑制血管新生,在炎症发生和血管生成中起重要作用。鉴于IP-10此特性,认为其在妊娠期高血压疾病的发病中起重要作用。综述IP-10在妊娠期高血压疾病发病机制中的作用。 Hypertensive disorder complicating pregnancy （HDCP） is a major cause of maternal and pefinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that HDCP has a number of pathophysiological characteristics including endothelial cell dysfunction, an anti-angiogenic state, intravascular inflammation. Interferon （IFN）-γ inducible protein, CX- CL10/IP-10, is a member of the CXC chemokine family with proinflammatory and anti-angiogenic properties. This chemokine has been proposed to be a key link between inflammation and angiogenesis. We propose that IP-10 is involved in the pathophysiology of HDCP because this condition is characterized by intravascular inflammation and an anti-angiogenic state. The present article analyses and reviews the roles of IP-10 in the etiology of HDCP
作者 王建芳 黄引平
机构地区 温州医学院附属第一医院妇产科
出处 《国际妇产科学杂志》 CAS 2009年第3期199-202,共4页 Journal of International Obstetrics and Gynecology
关键词 干扰素诱导蛋白10 妊娠期高血压疾病 炎症反应 抑制血管生成 IFN-γ, Inducible Protein 10 Hypertensive disorder complicating pregnancy Inflammation Anti-angiogenesis
分类号 R714.2 [医药卫生—妇产科学]
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参考文献20

  • 1Gotsch F, Romero R, Friel L,et al. CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia? [J]. J Maternal-Fetal Neonat Med, 2007,20 ( 11 ): 777-792.
  • 2Hanna J, Goldman-Wohl D, Hamani Y, et al. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface[J].Nat Med, 2006, 12(9):1065-1074.
  • 3Hirota Y, Osuga Y, Koga K, et al. The expression and possible roles of chemokine CXCLI 1 and its receptor CXCR3 in the human endometrium [J]. Immunology, 2006, 177(2):8813-8821.
  • 4Dominguez F, Martinez S, Quinonero A, et al. CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines [J]. Mol Hum Reprod, 2008, 14(7):423-430.
  • 5Jonsson Y, Ruber M, Matthiesen L, et al. Cytokine mapping of serafromwomen with preeclampsia and normal regnancies [J]. Reprod Immunol, 2006, 70(1/2) : 83-91.
  • 6Maynard SE, Min JY, Merchan J,et al. Excess placental soluble fins-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia [J]. Clin Invest, 2003, 111 (5):649-658.
  • 7Tsatsaris V, Coffin F, Munaut C, et al. Overexpression of the soluble vascular endothelial growth factor receptor in preeelamptie patients: Pathophysiological consequences [J].Clin Endocrinol Metab, 2003, 88( 11 ): 5555-5563.
  • 8Koga K, Osuga Y, Yoshino O, et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia [ J ]. Clin Endocrinol Metab, 2003,88 (5):2348- 2351.
  • 9Maynard SE, Min JY, Merchan J,et al. Excess placentalsoluble fins-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia[J]. Clin Invest, 2003, 111 (5):649-658.
  • 10Romagnani P, Annunziato F, Lasagni L, et al. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity[J]. Clin Invest, 2001,107( 1 ): 53-63.

同被引文献15

  • 1王一鹏,李颖,王树玉,段文卓.子痫前期的病理生理学研究进展[J].中国优生与遗传杂志,2006,14(9):127-128. 被引量：7
  • 2Luster AD, Unkeless JC, Ravetch JV. Gamma-interferon transcriptionally regulates an early-response gene contai- ning homology to platelet proteins [ J ]. Nature, 1985,315 (6021) :672-676.
  • 3Gotsch F, Romero R, Friel L, et al. CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia? [ J ]. J Matern Fetal Neonatal Med, 2007,20 ( 11 ) :777-792.
  • 4Boij R, Svensson J, Nilsson-Ekdahl K, et al. Biomarkers of coagulation, inflammation, and angiogenesis are independ- ently associated with preeclampsia [ J]. Am J Reprod Im- munol, 2012 [ Epub ahead of print ]. doi: 10. llll/j. 1600-0897. 2012. O1158. x.
  • 5Livak KJ, Schmittgen TD. Analysis of relative gene ex- pression data using real-time quantitative PCR and the 2 [ -Delta Delta C (T) ] Method [ J ]. Methods, 2001,25 (4) :402-408.
  • 6Jonsson Y, Ruber M, Matthiesen L, et al. Cytokine map- ping of sera from women with preeclampsia and normal pregnancies [ J ]. J Reprod Immnnol, 2006,70 ( 1-2 ) : 83- 91.
  • 7Sykes L, Macintyre DA, Yap X J, et al. The Thl : th2 di- chotomy of pregnancy and preterm labour[ J ]. Mediators Inflamm, 2012,2012 : 967629.
  • 8Dominguez F, Martinez S, Quinonero A, et al. CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines[ J]. Mol Hum Reprod,2008,14(7) :423-430.
  • 9Gotsch F, Romero R, Espinoza J, et al. Maternal serum concentrations of the chemokine CXCL10/IP-10 are ele- vated in acute pyelonephritis during pregnancy [ J ]. J Matern Fetal Neonatal Med,2007,20(10) :735-744.
  • 10漆洪波,石岩.子痫前期及子痫的诊治进展[J].中华妇幼临床医学杂志（电子版）,2009,5(1):2-4. 被引量：15

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国际妇产科学杂志
2009年 第3期

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