摘要
对三种ＤＴＰＡ双芳酰胺钆配合物用作肝胆磁共振成象造影剂进行了研究．配合物的亲脂性通过正辛醇－水分配比进行表征，结果表明实验值与理论值有很好的线性关系．蛋白结合实验表明亲脂性较强的配合物具有较强的蛋白结合能力．家兔的活体磁共振成象表明，将芳香环引入配合物中可以实现肝细胞对配合物的特异性摄取．
Three aromatic DTPA bis(amide) gadolinium complexes have been investigated for use as hepatobiliary contrast agents for magnetic resonance imaging. The lipophilicity of the complexes was determined by means of octanol buffer partition coefficient. The measured and theoretical lipophilicity exhibited good correlation. Protein binding studies show that the more lipophilic complex has higher BSA binding affinity. T 1 weighted spin echo images of rabbits demonstrated hepatobiliary specific uptake and excretion could also be achieved by adding aromatic rings to the molecule of a paramagnetic complex and were sensitive to the substituents on the aromatic rings.
出处
《波谱学杂志》
CAS
CSCD
北大核心
1998年第3期217-222,共6页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金
国家教委博士点基金
关键词
磁共振成象造影
DTPA双芳酰胺
肝胆造影剂
钆
Magnetic resonance imaging, Aromatic DTPA bis(amide), Hepatobiliary contrast agents, Gadolinium
