期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗HIV药物及其靶点的研究进展 被引量：8

Advance on targets and drugs for anti-HIV
原文传递
导出
摘要 随着AIDS在全球范围内的迅速蔓延,寻找有效的抗HIV药物成为研究的重点任务。作者主要综述了近10年来抗HIV药物作用靶点的研究进展,特别是以侵入融合过程、逆转录酶、蛋白酶及整合酶这几个位点,以及在这几个靶点上的传统中草药中抗HIV的有效成分,和已经用于临床及正在研发的一些抗HIV药物。 As the spreading of AIDS over the world, to research effective anti-HIV drugs is required. The review contains the process of discovering targets for anti-HIV especially entry/infuse, reverse transcriptase, protease and integrase, and describes the effective component of traditional Chinese drugs for these targets and the anti-HIV drugs being researched or used in clinic.
作者 王霞 马洪涛 温瑞兴
机构地区 北京工业大学生命科学与工程学院
出处 《中国中药杂志》 CAS CSCD 北大核心 2009年第11期1454-1459,共6页 China Journal of Chinese Materia Medica
基金 北京市自然科学基金项目(7092007)
关键词 抗HIV 吸附融合 逆转录酶 蛋白酶 整合酶 药物 anti-HIV entry/infuse reverse transcriptase protease integrase drugs
分类号 R287 [医药卫生—中药学]
  • 相关文献

参考文献52

  • 1Fletcher C V. Enfuvirtide. A new drug for HIV infection [ J]. Lancet, 2003,361 : 1577.
  • 2P F Lin, Wabe B, T Wang, et al. A small molecule HIV-1 inhibitor that targets the H1V-1 envelope and inhibits CD4 receptor binding[J]. Proc Natl Acad Sci USA, 2003,100:11013.
  • 3J M Jacobson, R J Israel, I Lowy, et al. Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542 [ J ]. Ant Agent Chem, 2004,48:423.
  • 4Davied A P, Simon G. Initial synthesis of UK-427857 ( maraviroc) [ J ]. Tetrahedon Lett, 2005,46 ( 30 ) :5005.
  • 5Jules Levin. SCH-D, CCR5 receptor inhibitor, new HIV drug in new class of drugs: Anliviral effect, safety, pharmacokinetics, susceptibility[ M]. 11 th Annual Retrocirus Conference, 2004, 2:8.
  • 6Hendrix C W, Collier A C, Lederman M M, et al. Safety pharmacokinctics and antiviral activity of AMD3100, a selective CX- CR4 receptor inhibitorin HIV-1 infection[ J]. J Acquir Immune Deft c Syndr, 2004,37:1253.
  • 7Moyle G, DeJesus E, Boffito M, et al. CXCR4 antagonism: proof of activity with AMD11070 [ C ]. Los Angeles: 14 th Confer ence on Retroviruses and Opportunistic Infection, 2007, (2) :25.
  • 8Balzarini J, K Van Laethem, S Hatse, et al. Profilie of 573 resistance of human immunodeficiency virus to mannose-specific plant lectins [ J ]. J Virol, 2004,78 : 10617.
  • 9Tamma S M, Kalyanaraman V S, Pahwa S, et al. The lectin jacalin induces phosphorylation of ERK and JNK in CD4^+ T cells [ J ]. J Leukocyte Biol, 2003,73 (5) :682.
  • 10K Yoganathan, Rossant C, Siewbee N, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum[ J]. J Nat Prod, 2003,66 : 1116.

二级参考文献75

  • 1温瑞兴,刘兆梅,杨怡姝,王小利.青龙爪、佛遗果等中药抑制艾滋病毒的初步研究[J].中国中药杂志,2007,32(4):355-357. 被引量：1
  • 2中华人民共和国卫生部.中国艾滋病防治工作情况[M].,2002..
  • 3火树华.树木学[M].2版.北京:中国林业出版社,1994.
  • 4Lee K S, Lig, Km S H, Lee C S, et al. Cytotoxic diarylhep tanoids from the roots of Juglans manshurica [ J ]. J Nat P rod, 2002,65(11 ) :1707.
  • 5Ahn C B, Song C H, Km W H, et al. Effects of Juglans sinensis Dode extract and antioxidant on mercurychloride-induced acute renal failure in rabbits[J]. J E thnop Hannacol, 2002,82(1) : 45.
  • 6Mnb S, Miya Shiroh, Hattor I M. Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase [ J ]. Phytother Res, 2002, ( Supp 1 ) 1 : s57.
  • 7温瑞兴,闫红,刘兆梅,等.中医药发展与人类健康.下册[M].北京:中医古籍出版社,2005,11:1301.
  • 8Per-Olof Markgren, Maria T Lindgren, Karl Gertow, et al. Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology [ J ]. Anal Biochem, 2001,291:207.
  • 9Per-Olof Markgren, Markku Hamalainen, U Helena Danielson. Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology [ J]. Anal Biochem, 1998,265: 340.
  • 10Per-Olof Markgren, Markku Hamalainen, U Helena Danielson. Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical hiosensor technology [ J ]. Anal Biochem, 2000,279:71.

共引文献68

同被引文献94

引证文献8

二级引证文献43

中国中药杂志
2009年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部