摘要
目的通过比较大肠癌患者和健康人脂联素在血清中的浓度，研究其与大肠癌之间的关系，为大肠癌的早期诊断和治疗做初步研究。方法对38例大肠癌患者和38例健康人采取新鲜血清应用酶联免疫吸附试验（enzyme—linked immunosorbent assay，ELISA）测定脂联素的浓度，分析之间是否存在差异，及分析不同肿瘤组织病理分期、不同肿瘤大小等因素与脂联素浓度的关系。结果大肠癌患者的血清脂联素水平159．89pg／mL明显低于健康对照组184．5pg／mL（P=0．001）。P53的表达与患者血清脂联素水平无相关性（P=0．678）。不同Dukes分期间的脂联素水平差异无统计学意义。但肿瘤超过5cm的患者脂联素平均水平144．86pg／mL，明显低于肿瘤小于5cm患者脂联素平均水平178．47pg／mL（P=0．04）。结论低水平的血清脂联素浓度与大肠癌发生有关，并且血清脂联素浓度与肿瘤大小有着负相关，可以推测脂联素在大肠癌的发生、发展过程中起重要作用。
Objective By comparing the plasma levels of adiponectin respectively in colorectal carcinoma patients to healthy controls to discuss the relationship between adiponectin and colorectal carcinoma. Methods Plasma samples collected from 38 colorectal cancer cases, 38 healthy controls, respectively, were analyzed with a specific ELISA assay. Results The mean adiponectin levels in colorectal cancer patients and healthy controls were 159.89 and 184.5 pg/mL, respectively. Obviously colorectal cancer patients had significantly lower plasma adiponectin concentrations compared with healthy controls（ P = 0.001 ）. And a inverse correlation was found between plasma adiponectin levels and tumor size with significantly lower levels of adiponectin in tumors ≥ 5 cm （P = 0.04）, while no similar relationship was found between adiponectin and p53, Dukes Stages （P 〉 0.05）. Conclusions Lower plasma levels of adiponectin are associated with colorectal carcinogenesis closely. And the lower plasma levels of diponectin were positively related to the degree of tumor size. It can presume that adipenectin play a vital role in the process of colorectal carcinogenesis.
出处
《国际外科学杂志》
2009年第5期308-310,共3页
International Journal of Surgery
