摘要
目的探讨孕中期二联法产前筛查对胎儿染色体异常及神经管缺陷的作用及不足。方法对武汉地区20930例孕14-20周的孕妇进行血清AFP和Free-βHCG浓度的检测,结合孕周、体重、年龄等因素,通过风险评估软件进行风险评估。再将结果与B超、羊水、新生儿检查结果对照。结果筛查染色体高风险有1064例,确诊染色体异常16例,已知染色体异常假阴性结果5例(漏筛)。筛查神经管缺陷高风险159例,通过B超确诊为神经管缺陷胎儿48例。结论在特定孕期对孕妇血清指标AFP、Free-βHCG检查,在一定程度上有利于降低先天性缺陷儿的出生率;同时由于二联法本身的局限性,存在较高漏筛率。
Objective： Discuss the effects and shortages which are taken from duplex process prenatal screening in the pregnant woman＇s medium term of pregnancy to the fetus＇s chromosomal abnormalities and neural tube defect. Methods： Did serum AFP and Free - βHCG concentration detection to 20930 pregnant women in Wuhan those were pregnant for 14 - 20 weeks. With factors of chil- dren weeks, avoirdupois age and so on, we evaluated the risk with risk evaluation software. Then compared the results whit type - B ultrasonic, amniocentesis, and results of the newborn＇s examination. Results ： 1064 examples with chromosome high risk were detected. 16 chromosomal abnormalities were diagnosed which contain 5 examples misdiagnosis. 159 examples with neural tube defect high risk were checked. 48 fetuses with neural tube defect were diagnosed. Conclusion ： Examine the pregnant woman＇s serum AFP and Free - βHCG in the special period of her pregnancy, to a certain extent , which is good for the reduction of congenital birth defect child＇s birth rate. However, because of the limitation of duplex process, the misdiagnosis is higher.
出处
《中国优生与遗传杂志》
2009年第6期28-30,共3页
Chinese Journal of Birth Health & Heredity
关键词
产前筛查
高风险
Prenatal screening
High risk
