摘要
目的：探讨孕妇血清标记物甲胎蛋白（ＡＦＰ），绒毛膜促性腺激素（β－ｈＣＧ），游离雌三醇（ｕＥ３）在孕中期胎儿缺陷的产前筛选中的作用。方法：对６７７例中期妊娠妇女进行上述三联血清标记物检测，对可能影响检测结果的部分因素，如孕妇体重、孕周等在分析时加以较正。每例筛选的孕妇均追踪到胎儿出生。结果：在被筛选孕妇中，有１１例血清标记物异常的孕妇被确诊为胎儿异常，阳性检出率为１．６％，３２例孕妇筛选结果为假阳性，假阳性率为４．７％。另有１１例孕妇发生孕中期死胎，但经检查均为非胎儿因素致死。结论：上述三联血清标记物检测。
Objective: To investigate the effect of secondtrimester maternal serum markers AFP, βhCG, uE3, for prenatal screening of the fetal defects. Methods: In 677 women the triple markers were measured. Some factors that may affect the testing such as maternal weight, gestational age, were adjusted on analyzing the result of the testing. Each woman, who underwent the triple screening, will be followed up until her fetus was delivered. Results: Among the women who were screened, 11 patients who presented at least one marker positive were identified as having an abnormal fetus, and the positive rate was 1.6%. While 32 women were confirmed to be false positive with a rate of 4.7%. Another 11 women had fetal demise on secondtrimester, which had been proved to be not caused by fetal abnormality. Conclusion: Maternal triple serum markers may take as a routine protocol for prenatal screening of the fetal defects.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第11期649-651,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
产前诊断
胎儿
神经管缺陷
染色体异常
Prenatal diagnosis Neural tube defects Chromosome abnormalities Alpha fetoproteins Estriol
