摘要
目的:制备艾塞那肽-乳酸/羟基乙酸共聚物(PLGA)微球,并研究PLGA分子量对微球性质的影响。方法:选用不同分子量的PLGA,采用复乳法制备艾塞那肽PLGA微球;对微球的粒径、载药量、包封率和体外释放等指标进行测定。结果:PLGA分子量对艾塞那肽PLGA微球的性质有明显影响。结论:可通过调节PLGA分子量调控微球的性质。
Objective：To prepare exenatide-loaded poly （lactic-co-glycolide acid） （PLGA） microsphere, to evaluate the effect of molecular weight of PLGA on properties of these microspheres. Methods： The exenatide-loaded PLGA microspheres were prepared by double emulsion method with PLGA of different molecular weight. Parameters including particle size, drug loading, encapsulation, and releasing in vitro were determined. Results： The molecular weight of PLGA showed a significant effect on the property of exenatide-loaded PLGA microspheres. Conclusion： The expected characteristics of the microspheres can be realized by adjusting the molecular weight of PLGA.
出处
《中国当代医药》
2009年第9期117-118,共2页
China Modern Medicine
关键词
艾塞那肽
微球
乳酸/羟基乙酸共聚物
分子量
Exenatide
Microspheres
Poly（lactic-co-glycolide）acid
Molecular weight
