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Exendin-4与糖尿病治疗 被引量:8

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出处 《重庆医学》 CAS CSCD 2006年第10期904-906,共3页 Chongqing medicine
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  • 1Eng J,KleinmanWA,Singh L,et al.Isolation and characterization of exendin-4,an exendin-3 analogue,from Heloderma suspectum venom:further evidence for an exendin receptor on dispersed acini from guinea pig pancreas[J].J Biol Chem,1992,267:7402
  • 2Schepp W,Schmidtler J,Riedel T,et al.Exendin-4 and exendin-(9-39)NH2:agonist and antagonist,respectively,at the rat parital cell receptor for glucagon-like peptide-1-(7-36)NH2[J].Eur J Pharmacol,1994,269:183
  • 3Fehmann HC,Jiang J,Schweinfurth J,et al.Stable expression of the rat GLP-1 receptor in CHO cells:activation and binding characteristics utilizing GLP-1(7-36)-amide,oxyntomodulin,exendin-4,and exendin(9-39)[J].Peptides,1994,15:453
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  • 5Kieffer TJ,Mcintosh CH,Pederson RA.Degradation of glucose-dependent insulin otropic polypeptide and truncate glucagon-like peotide-1 in vitro and in vivo by dipeptidylpeptidaseⅣ[J].Endocrinology,1995,136:3585
  • 6Hansen L,Deacon CF,Orskov C,et al.Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase Ⅳ in the capillaries supplying the L cells of porcine intestine[J].Endocrinology,1999,140:5356
  • 7Bhavsar S,Lachappell R,Watkins J,et al.Comparison of glucose-lowering effects of exendin-4 and GLP-1 in diabetic db/db mice(Abstract)[J].Diabetes,1998,147:192A
  • 8Bodkin N,Hansen B,Young A.Dose response for glucose lowering by exendin-4 in diabetic rhesus monkeys(Macaca mulatta)(Abstract)[J].Diabetes,1998,47:93A
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  • 10Nakazaki A,Hu M.cAMP-activated protin kinase-indepenent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets[J].Diabetes,2002,51(12):3440

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