摘要
目的:探讨伽玛刀治疗颅内肿瘤并发放射性脑损伤的MRI影像表现及其组织病理学基础。方法:回顾性分析8例经手术及病理证实的放射性脑损伤的MRI表现;其中,星形胶质细胞瘤4例,转移性腺癌2例,血管母细胞瘤1例,鼻咽癌1例。结果:病变位于小脑半球、额叶、颞叶及顶叶,8例9个病灶共有2种MRI表现:5例6个病灶平扫T1WI呈低、等信号,T2WI呈稍高、高信号,增强扫描呈"结节状"、"花环状"强化;3个病灶平扫为类圆形,T1WI呈均匀低信号,T2WI呈高信号,边界清楚,增强扫描囊腔无强化,囊壁轻度均匀强化。所有病例均有占位效应。结论:伽玛刀所致放射性脑损伤具有一定的特征性,特别是囊状坏死。
Objective： To evaluate the characteristics of MRI and histopathology of brain radiation necrosis following radiotherapy for brain neoplasm by γ-knife. Methods： MRI findings of 8 patients with brain radiation necrosis following radiotherapy for brain neoplasm by γ-knife were reviewed, including 4 cases of astrocytoma, 2 metastatic adenocareinoma, 1 hemangioblastoma, and 1 nasopharyngeal carcinoma. Results： The brain radiation necrosis lesions occurred in the hemispherium eerebelli, front lobe, temporal lobe, and parietal lobe, respectively. Eight patients （9 lesions） underwent routine and contrast enhanced MRI scan and two MRI features were found： T1WI showed that there was low signal intensity or iso-intensity, and T2 WI showed high signal intensity in 6 lesions （5 patients）. T1WI plus Gd-DTPA showed gyrus or irregular rings of enhancement in lesions. And other typical MRI feature was cyst liq uefaction, and T1WI showed a well-demarcated and rounded low signal intensity, and T2WI showed high intensity in 3 lesions. T1WI plus Gd-DTPA showed no enhancement on the cystic wall or a small enhancement. All the cases had space-occupying effect. Conclusion.. The MRI finds are specific in brain radiation necrosis following radiotherapy for γ-knife, especially in cystic necrosis.
出处
《华西医学》
CAS
2009年第5期1198-1201,共4页
West China Medical Journal
关键词
伽玛刀
放射治疗
放射性脑损伤
脑肿瘤
磁共振成像
γ-knife
radiotherapy
brain radiation necrosis
brain tumor
magnetic resonance imaging
