摘要
目的:研究葛根素对急性脑缺血缺氧所致脑神经细胞损伤的保护效应。方法:完全阻断大脑中动脉30min致其所支配的特定区域缺血缺氧,制作大鼠急性脑缺血损伤模型;药物组预先给予葛根素注射液,对照组给予等容量的0.9%氯化钠溶液;观察和比较两组脑神经细胞损伤的病理形态学变化,计算其脑神经细胞的死亡率和葛根素干预后的保护关联强度。结果:葛根素组的脑神经细胞损伤程度轻于0.9%氯化钠溶液对照组,葛根素干预与脑神经细胞死亡呈显著负相关。结论:葛根素对急性脑缺血所致的脑神经细胞损伤具有一定的保护作用。
Objective ： To study the protection of puerarin on the impaired brain cell with ischemia. Method ： The rat model of acute local cerebral ischemia was reproduced by fully blocking the middle cerebral artery for 30rain. Rats of puerarin preventing group were injected with puerarin in dose of 30 mg-kg 1 by intraperitoneal injection before ischemia 30 minutes, while the control group were injected with equal value of saline. The changes of morphology and mortality of brain cell were compared between the two groups. The protective strength of association of the puerarin was calculated. Result： The lesion of brain cells in the puerarin preventing group was much slighter than that in the control group. Significantly negative correlation between the protection of puerarin and the death rate of brain cells was observed. Conclusion： Puerarin has the neuroprotection in the processes of acute cerebral ischemia.
出处
《中国药师》
CAS
2009年第6期704-706,共3页
China Pharmacist
关键词
葛根素
脑缺血
脑细胞
Puerarin
Cerebral ischemia
Brain cell
