摘要
观察家兔髂动脉球囊损伤后葛根素抑制损伤部位平滑肌细胞增殖的药效。复制球囊损伤家兔髂动脉造成血管狭窄模型 ,实验分为 5 0mg (kg·d)葛根素治疗组、10 0mg (kg·d)葛根素治疗组和手术对照组 ,通过体外超声定期检测血管腔直径 ,病理切片观察血管内膜和中膜面积。结果发现 ,球囊损伤术后第 5周 5 0mg (kg·d)葛根素治疗组的血管直径 (1.6 6± 0 .4 1mm)和 10 0mg (kg·d)葛根素治疗组的血管直径 (1.5 9± 0 .17mm)显著高于对照组(1.13± 0 .4 3mm)。病理切片结果发现 10 0mg (kg·d)葛根素治疗组内膜 /中膜面积比 (36 %± 18% )显著低于对照组(12 4 %± 6 4 % )。结果提示 ,葛根素对球囊损伤术后血管平滑肌细胞增殖有一定抑制作用。
Aim To verify the puerarin anti-smooth muscle cell proliferation effect through treating rabbit artery balloon injury. Methods The rabbit iliac artery balloon injury model was duplicated, then treated with 50 mg/(kg·d), 100 mg/(kg·d) puerarin or without treatment. The diameter of iliac artery was measured by ultrasound equipment. The intima, media and blood vessel areas were measured by slide image analysis system. Results Five weeks after the operation, the 50 mg/(kg·d) treated group's iliac artery diameters (1.66±0.41 mm) were wider than control group's (1.13±0.43 mm), so did 100 mg/(kg·d) puerarin group's, and ratio of intima to media area of 100 mg/(kg·d) puerarin group was also lower than the control's. Conclusion Puerarin has effect of preventing stenosis after balloon injury.
出处
《中国动脉硬化杂志》
CAS
CSCD
2004年第2期159-161,共3页
Chinese Journal of Arteriosclerosis
基金
北京市科委重点实验室资助 ( 95 3 85 0 70 0 4)项目
