摘要
目的：探讨进一步提高慢性再生障碍性贫血（ＣＡＡ）疗效的方法。方法：长效睾丸酮（ＴＬＤ）单用（１５例）及合用环孢霉素Ａ（ＣｓＡ）（３０例）治疗ＣＡＡ４５例。按全国统一标准评定疗效，并采用甲基纤维素培养法观察治疗前、后骨髓造血祖细胞水平的变化。结果：ＴＬＤ＋ＣｓＡ组有效率为８３．３％，高于单用ＴＬＤ组的６０．０％，且ＴＬＤ＋ＣｓＡ组有效者骨髓造血祖细胞（ＢＦＵ－Ｅ及ＣＦＵ－ＧＭ）恢复明显优于单用ＴＬＤ组有效者并更为迅速，两组间无效者骨髓ＢＦＵ－Ｅ及ＣＦＵ－ＧＭ水平无明显变化。结论：ＴＬＤ＋ＣｓＡ治疗ＣＡＡ疗效不仅高于单用ＴＬＤ，且其有效者血液学恢复更为完全。
Objective:To explore more effective regimen for chronic aplastic anemia (CAA). Methods:Fortyfive cases of CAA were treated with triolandren (TLD) (15 cases) or TLD and cyclosporin A (CsA) (30 cases). Results: The response rate of TLDCsA group (83.3%) was higher than that of TLD group (60.0%), furthermore, the recovery of bone marrow colonyforming cell (CFC) number of the responding patients was more complete and rapid in TLDCsA group than in TLD group. Bone marrow CFC number had no significant change of all nonresponding patients in both groups. Conclusion:The response rate of TLDCsA was higher than that of TLD alone, and the recovery of bone marrow CFC number of the responding patients was more complete and rapid in TLDCsA group.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1998年第4期175-177,共3页
Chinese Journal of Hematology
