摘要
目的:评估含蘑菇葡聚糖、维生素K_1的医学护肤品(商品名:薇诺娜舒颜祛红血丝修复霜)对面部毛细血管扩张症的有效性和安全性。方法:31例面部毛细血管扩张症患者外用薇诺娜舒颜祛红血丝修复霜,每日1次,共60 d,于治疗后30d和60 d各随访1次,观察疗效和不良反应,并对其中20例进行无创性功效测试。结果:30例患者完成本次试验,使用薇诺娜舒颜祛红血丝修复霜60 d后,面部皮肤紧绷不适感改善率为26.7%,瘙痒改善率为22.2%,对毛细血管扩张症有效率为20.0%。20例患者治疗后30 d和60 d皮肤受试部位红斑指数降低,与治疗前比较差异无统计学意义(P>0.05)。经皮水分丢失值逐渐降低,差异有统计学意义(P<0.01)。4例患者局部有轻微刺激反应,均未给予特殊处理,最终自行缓解。结论:薇诺娜舒颜祛红血丝修复霜局部外用对面部毛细血管扩张症安全、有效。
Objective： To evaluate the clinical efficacy and safety of topical cream containing β-glucan （ extracted from mushroom） and vitamin K1 in the treatment of facial telangiectasia. Methods： Thirty-one patients with facial telangiectasia were treated with topical cream containing β-glucan and vitamin K1 once daily for two months. The clinical manifestation and adverse reactions were observed and recorded when following-up at the day 30 and 60 of the trial. The stratum corneum hydration and TEWL were measured with non-invasive methods in 20 out of 31 patients. Results： The trial was completed in 30 patients, including 29 females and 1 male, at the age of 23 to 45 years（31.67±8.64）. After 60-day treatment, the remission rate of skin tightness and itching was 26.7% and 22.2% respectively, and the improvement rate of facial telangiectasia was 20.0%. The index of haemachrome at the tested skin was decreased after 60 days in 20 subjects（P〉 0.05）, the level of TEWL decreased gradually during the treatment （P〈0.01）. Mild sting and itching were observed in 4 patients after the first application. Conclusion： The topical cream containing β-glucan and vitamin K1 is safe and effective in patients with facial telangiectasia.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2009年第6期355-357,共3页
Journal of Clinical Dermatology
