期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

皮肤MALT淋巴瘤缺乏t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1 被引量：1

ABSENCE OF t(11;18)(q21;q21)/API2-MALT1 AND t(14;18)(q34;q21)/IGH-MALT1 IN PRIMARY CUTANEOUS MALT LYMPHOMA
暂未订购
导出
摘要 目的:探讨黏膜相关淋巴组织(MALT)淋巴瘤中常见的两个染色体易位t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1在皮肤MALT淋巴瘤中的发生率。方法:采用MALT1及IGH双色分离探针,对19例皮肤MALT淋巴瘤标本进行间期荧光原位杂交(FISH)。结果:19例皮肤MALT淋巴瘤中均未检测到涉及MALT1基因的染色体易位,但发现2例(2/19,11%)存在MALT1基因的3个拷贝现象。结论:涉及MALT1基因的染色体易位,即t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH-MALT1在皮肤MALT淋巴瘤罕见或不见。 Objective.t（ll;18）（q21;q21）/API2-MALT1 and t（14;18）（q34;q21）/IGH-MALT1 have been reported in cutaneous MALT lymphoma. However, the incidence of t（11;18）（q21;q21）/API2-MALT1 and t（14;18）（q34;q21）/IGH-MALT1 in this kind of cutaneous lymphoma remains unclear. Methods. 19 cases of cutaneous MALT lymphoma were screened by interphase FISH analysis using MALT1 and IGH break apart probes. Results： The translocations involving MALT1 were not detected in all of the 19 cutaneous MALT lymphoma, but 3 copies of MALT1 gene were detected in two of the 19 cases （11%） . Conclusion：This study demonstrated that translocations involving MALT1 gene, including API2-MALT1 and IGH-MALT1 are absence or at least uncommon in cutaneous MALT lymphoma.
作者 周英琼 宫丽平 侯巧燕 肖胜军 郭芳 叶洪涛
机构地区 桂林医学院附属医院病理科 首都医科大学病理系
出处 《广西医科大学学报》 CAS 2009年第2期197-199,共3页 Journal of Guangxi Medical University
基金 国家自然科学基金(30760081) 广西自然科学基金(桂科自0499015和桂科自0848012) 广西病理学人才小高地创新团队
关键词 皮肤 MALT淋巴瘤 染色体易位 FISH skin MALT lymphoma translocation FISH
分类号 R733.4 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Isaacson PG,Du MQ.MALT lymphoma:from morphology to molecules[J].Nat Rev Cancer,2004,4(8):644-653.
  • 2Ye H,Liu H,Attygalle A,et al.Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites:significant association with CagA strains of H pylori in gastric MALT lymphoma[J].Blood,2003,102(3):1 012-1 018.
  • 3Isaacson PG,Muller-Hermelink HK,Piris MA,et al.Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)[M]//Jaffe ES,Harris NL,Stein H,et al.World Health Organization Classification of Tumours.Pathology and Genetics:Tumours of Haemopoietic and Lymphoid Tissues.Lyon:IARC Press,2001:157-160.
  • 4王桂秋,周英琼,宫丽平,冯震博,董格红,高子芬,叶洪涛.用荧光原位杂交在石蜡切片上检测t(11;18)和涉及bcl-10基因染色体易位的方法[J].中华病理学杂志,2007,36(7):494-495. 被引量：27
  • 5Gronbaek K,Ralfkiaer E,Kalla J,et al.Infrequent somatic Fas mutation but no evidence of Bcl10 mutation or t(11;18) in primary cutaneous MALT-type lymphoma[J].J Pathol,2003,201(1):134-140.
  • 6Espinet B,Gallardo F,Pujol RM,et al.Absence of MALT1 translocations in primary cutaneous marginal zone B-cell lymphoma[J].Haematolllogica,2004,89(9):ELT14.
  • 7Wongchaowart NT,Kim B,His ED,et al.t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas[J].J Cutan Pathol,2006,33(4):286-292.
  • 8Hallermann C,Kaune KM,Gesk S,et al.Molecular cytogenetic analysis of chromosomal breakpoints in the IGH,MYC,BCL6,and MALT1 gene loci in primary cutaneous B-cell lymphomas[J].J Invest Dermatol,2004,123(1):213-219.
  • 9Streubel B,Simonitsch-Klupp I,Mullauer L,et al.Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites[J].Leukemia,2004,18(10):1 722-1 726.
  • 10Schreuder MI,Hoefnagel JJ,Jansen PM,et al.FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma[J].J Pathol,2005,205(3):302-310.

二级参考文献5

  • 1Jaffe ES, Harris NL, Stein H, et al. World Health Organization of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon :IARC Press, 2001.
  • 2Ye H, Liu H, Attygalle A, et al. Variable frequencies of t(11 : 18 ) ( q21 ;q21 ) in MALT lymphomas of different sites : significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood ,2003,102( 3 ) : 1012-1018.
  • 3Remstein ED, Kurtin PJ, Buno I, et al. Diagnostic utilily of fluorescence in situ hybridisation in mantle-cell lymphoma. Br J Haematol,2000,110 ( 4 ) :856-862.
  • 4Paternoster SF, Brockman SR, McClure RF, et al. A new method to exlract nuclei from paraffin-embedded tissue to study lymphomas using interphase fluorescence in situ hybridisation. Am J Pathol, 2002,160 ( 6 ) : 1967 - 1972.
  • 5Einerson RR, Kurtin PJ, Dayharsh GA,et al. FISH is superior to PCR in detecting t ( 14; 18 ) ( q32; q21 )-IgH/bcl-2 in follicular lymphoma using paraffin-embedded tissue samples. Am J Clin Pathol,2005,124 ( 3 ) :421-429.

共引文献26

同被引文献7

引证文献1

二级引证文献1

广西医科大学学报
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部