免疫肠内营养支持对危重病患者细胞免疫功能及并发症的影响被引量：11

Effect of enteral immunonutrition on cellular immune function and complications in critically ill patients

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摘要目的:探讨免疫肠内营养支持对危重病患者细胞免疫功能及并发症的影响。方法:80例危重病患者随机分为免疫肠内营养组(研究组)和标准肠内营养组(对照组),每组40例,分别行鼻饲肠内营养支持10d。检测研究前后两组患者免疫指标、炎症反应指标的变化,记录两组患者住院期间感染性并发症的发生情况。结果:75例完成研究。研究结束时,研究组CD3、CD4、CD4/CD8及NK细胞活性显著高于对照组(P<0.01),而IL-6及TNF-α显著低于对照组(P<0.01)。两组患者感染性并发症的发生率比较,无显著性差异(P>0.05),但研究组的感染持续天数明显短于对照组(P<0.05)。结论:含精氨酸、谷氨酰胺及ω-3脂肪酸的免疫肠内营养可以改善危重病患者的细胞免疫功能,减轻炎症反应,预防感染性并发症的发生及发展。 Objective： To study the effect of enteral immunonutrition on cellular immune function and complications in critically ill patients. Methods： 80 critically ill patients were randomly divided into study group （n=40） which was given enteral immunonutrition and control group （n=40） which was given standard enteral nutrition. All patients received enteral nutrition by gastric tube for 10 days. Immune parameters and inflammatory response parameters were measured before and after the feeding. Infective complications were also recorded. Results： 75 of all cases completed the study. At the end of study, study group had significantly higher levels of CD3, CD4, CD4/CD8 and stronger activity of NK cells （P〈0.01） and lower levels of IL-6 and TNF-α （P〈0.01） than the control group. No statistical difference was found of infective complications in two groups （P〉0.05）. But study group experienced much shorter infective time than control group （P〈0.05）. Conclusion： Entetral imunonutrition including agrinine, glutamine and ω-3 fatty acids can improve cellular immune function, relieve inflammatory response and prevent the occurrence and progress of infective complications.

作者肖喜春

机构地区河南省商丘市第一人民医院血液内科

出处《中国医药导报》 CAS 2009年第16期20-22,共3页 China Medical Herald

关键词肠内营养危重病患者细胞免疫炎症反应感染 Enteral nutrition Critically ill patients Cellular immunity Inflammatory response Infection

分类号 R473.5 [医药卫生—护理学]

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参考文献7

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