摘要
目的探讨氟喹诺酮类药物所致癫痫的诱发因素,提高相应的预防措施。方法收集了四川省南充市精神卫生中心、南充市中心医院、川北医学院附属医院自2001年1月至2008年3月氟喹诺酮类药物所致癫痫发作的48例病例进行回顾性分析。结果氟喹诺酮类药物所致癫痫发作48例中,年龄(60岁30例(占62.5%),既往有抽搐或癫痫史12例,肾功能不全12例,患脑动脉硬化、脑梗塞者15例;引起癫痫发作的氟喹诺酮为环丙沙星21例、左氧氟沙星18例、氟罗沙星3例、诺氟沙星3例、氧氟沙星3例,静脉给药共42例,静滴时间为15-40分钟,口服6例;18例合用茶碱类药物,15例合用非甾体抗炎药。48例癫痫病例中,39例为大发作,9例为小发作,发作的开始时间在用药后30分钟-5天;患者均在停药或抗癫痫等对症治疗后,好转出院。结论临床医生、药师应掌握氟喹诺酮类药物所致癫痫发作的诱发因素,规范合理使用氟喹诺酮类药物,预防其导致癫痫发作。
Objective To understand the causes of seizures induced by fluoroquinolones, improve the corresponding preventive measures. Methods The reported cases with seizures induced by fluoroquinolones from Nanchong Mental Health Center, Nanchong Central Hospital, Affiliated Hospital of North Sichuan Medical College （2001.1-2008.3） were collected and analyzed. Results 48 patients with fluoroquinolones-induced seizures were collected. 30 cases were older than 60 years, 12 cases had a previous history of epilepsy, 12 cases of renal insufficiency, 15 cases accompanied with cerebral arteriosclerosis, cerebral infarction. Epileptic seizures caused by fluoroquinolone for 21 cases of ciprofloxacin, 18 cases of levofloxaein, 3 cases of fleroxaein, 3 cases of norfloxacin, 3 cases of ofioxacin, among them, 42 cases were intravenously administrated, infusion time was 15 -40 minutes, 6 cases were orally administrated. 18 patients were co-administered with theophylline-containing preparations, 15 cases were coadministered with non-steroidal anti-inflammatory drugs. Of the 48 patients, 39 were generalized tonic-elonic seizures, 9 were partial seizures. The time of onset of seizures was 30 rain to 5 d after fluoroquinolones use. After drug withdrawal or systematic therapy, 48 patients recovered and were discharged. Conclusion It was important for clinicians and pharmacists to know the predisposing factors of fluoroquinolone-induced epilepsy, and rational usage of the medicine.
出处
《川北医学院学报》
CAS
2009年第3期246-248,共3页
Journal of North Sichuan Medical College
