摘要
为探讨低分子肝素治疗不稳定型心绞痛（UAP）的疗效，将38例新近发生的静息性心绞痛持续时间＞15min的患者随机分组：A组（18例）给予口服阿司匹林（300mg／d）和抗心绞痛药物；B组（20例）给予阿司匹林和抗心绞痛药物加皮下注射低分子肝素（200IU／kgqd，连续7d）。结果：A组和B组在住院7d内再发心绞痛、非致死性心肌梗死、心性死亡、急救经皮腔内冠状动脉成形术分别为33％与10％、17％与0、11％与0和17％与5％，总的心性事件发生率为78％与15％（P＜0．01）．B组仅2例发生皮下瘀斑。表明UAP患者急性期用低分子肝素治疗有效、安全和便利。
To determine the therapeutic effectiveness of low molecular weight heparin (LMWH) in unstable angina pectoris(UAP),a total of 38 patients with UAP defined as recent onset and prolonged (≥15 min)and spontaneous rest pain entered the study. Patients were randomized to receive antianginal agents plus aspirin (300 mg/d [group A= 18]) and antianginal agents plus aspirin LMWH(200IU/kg once daily subcutaneously [group B= 20] ). Results showed recurrent angina, nonfatal myocardial infarction, cardiac death and urgent PTCA occurred in 33% vs 10%, 17 % vs 0, 11 %vs 0 and 17% vs 5% in group A and B,respectively. Total cardiac events occurred in 78% vs 15% in group A and B, (P<0. 01).Minor bleeding was detected in 2 patients in group B. Thus,treatment with LMWH during acute phrase of UAP was efficient,safe and convement.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1998年第3期157-158,共2页
Journal of Clinical Cardiology
